A mild and efficient palladium catalyzed [3+2] cycloaddition of vinyl aziridines and indane-1,3-diones has been realized. The resulting spiropyrrolidines were provided in excellent yields and, with the introduction of the leucine-derived phosphine ligand, moderate to good enantio- and diastereoselectivities.
Palladium catalyzed [3+2] cycloaddition of vinyl aziridine and indane-1,3-diones: diastereo- and enantioselective access to spiro-pyrrolidines / Vetica, Fabrizio; Bailey, Stephen J.; Kumar, Mukesh; Mahajan, Suruchi; Rissanen, Kari; von Essen, Carolina; Enders, Dieter. - In: SYNTHESIS. - ISSN 0039-7881. - 52:14(2020), pp. 2038-2044. [10.1055/s-0040-1707472]
Palladium catalyzed [3+2] cycloaddition of vinyl aziridine and indane-1,3-diones: diastereo- and enantioselective access to spiro-pyrrolidines
Vetica, Fabrizio
;
2020
Abstract
A mild and efficient palladium catalyzed [3+2] cycloaddition of vinyl aziridines and indane-1,3-diones has been realized. The resulting spiropyrrolidines were provided in excellent yields and, with the introduction of the leucine-derived phosphine ligand, moderate to good enantio- and diastereoselectivities.| File | Dimensione | Formato | |
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