Vascular senescence at the crossroad between oxidative stress and nitric oxide pathways: Disclosing the secret of dorian gray

Mitochondria play a critical role in maintaining the bioenergetic status of cells under physiological oconrditioins.gHoweivern, reducation olf oxypgen tougenerabte freelradicsals occhurs atevariours si.tes in the mitochondrial respiratory chain, affecting the availability of key regulators of vascular homeostasis. Indeed, several studies sugg est which triggers the development and progression of atherosclerosis in aging individuals and animal models. Among the potential mechanisms underlying age-related impairment of endothelial function, reduction of nitric oxide (NO) bioavailability due to its reaction with oxygen-derived free radicals plays a pivotal role. tha t mito ch ondrial -deriv ed rea ctive oxygen speci Unauthorised copying The present article focuses on the pathophysiology of vascular senescence and explores the interactions of ROS and NO pathways relevant to cardiovascular aging.