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EnglishPolymeric oral thin films (OTFs) were prepared by the casting method, combining gellan gum (GG), a water-soluble polysaccharide, and glycerol (Gly) as a plasticizing agent. GG-Gly films were investigated as potential systems for buccal drug delivery using fluconazole (Class I of the Biopharmaceutical Classification System) as a model drug. At a low concentration of Gly drug precipitation occurred while, for higher concentrations of Gly, a significant deterioration of mucoadhesive and mechanical properties was observed. One possible way to overcome all these problems could be the addition of hydroxypropyl-β-cyclodextrin (HP-β-CD) to the GG-Gly formulation as a drug-precipitation inhibitor. In this work the effect of cyclodextrin addition on the mechanical, mucoadhesive, swelling and release properties of GG-Gly films was investigated. In-vitro drug release studies were carried out using the paddle type dissolution apparatus (USP II) and the millifluidic flow-through device (MFTD). A moving-boundary model for swelling dynamics and release in USP II is proposed to estimate the effective diffusivity of the solvent, HP-β-CD, fluconazole and complex fluconazole/HP-β-CD in the swelling film. Experimental results, supported by theoretical modeling, confirmed that gellan gum-low glycerol thin films including HP-β-CD represent a suitable formulation for fluconazole drug delivery. A sustained release was observed when GG-Gly film is loaded with a preformed complex fluconazole/HP-β-CD.
Enhanced loading efficiency and mucoadhesion properties of gellan gum thin films by complexation with Hydroxypropyl-β-Cyclodextrin / Adrover, Alessandra; di Muzio, Laura; Trilli, Jordan; Brandelli, Chiara; Paolicelli, Patrizia; Petralito, Stefania; Casadei, Maria Antonietta. - In: PHARMACEUTICS. - ISSN 1999-4923. - 12:9(2020). [10.3390/pharmaceutics12090819]
| Titolo: | Enhanced loading efficiency and mucoadhesion properties of gellan gum thin films by complexation with Hydroxypropyl-β-Cyclodextrin | |
| Autori: | ||
| Data di pubblicazione: | 2020 | |
| Rivista: | ||
| Citazione: | Enhanced loading efficiency and mucoadhesion properties of gellan gum thin films by complexation with Hydroxypropyl-β-Cyclodextrin / Adrover, Alessandra; di Muzio, Laura; Trilli, Jordan; Brandelli, Chiara; Paolicelli, Patrizia; Petralito, Stefania; Casadei, Maria Antonietta. - In: PHARMACEUTICS. - ISSN 1999-4923. - 12:9(2020). [10.3390/pharmaceutics12090819] | |
| Handle: | http://hdl.handle.net/11573/1435467 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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| File | Note | Tipologia | Licenza | |
|---|---|---|---|---|
| Adrover_Enhanced_2020.pdf | Versione editoriale (versione pubblicata con il layout dell'editore) |  | Open Access Visualizza/Apri |
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