Chronic rhinosinusitis (CRS) includes two main phenotypes: without nasal polyps (CRSsNP) and with nasal polyps (CRSwNP). CRSwNP may be associated with comorbidity, mainly concerning asthma, aspirin intolerance, and allergy. CRSwNP patients may also be evaluated by clinical-cytological grading (CCG). The current study investigated the prevalence and characteristics of the different CCG and phenotypes in CRSwNP outpatients examined in clinical practice. This retrospective cross-sectional study enrolled 791 consecutive CRSwNP outpatients (424 males, mean age 48.8 years). In the total population, asthma was a common comorbidity (30.8%) as well as aspirin intolerance (24.8%), and allergy (50.8%). As concerns CCG-grading, 210 (26.5%) outpatients had low-grade, 366 (46.3%) medium, and 215 (27.2%) high. As regards cytological phenotypes, 87 (11%) had neutrophilic type, 371 (46.3%) eosinophilic, 112 (14.2%) mast cell, and 221 (27.9%) mixed. High-grade CCG was significantly associated with more frequent asthma, aspirin intolerance, allergy, recurrent surgery, and mixed cytological phenotype. Low-grade CCG was characterized by fewer comorbidities and operations, and neutrophilic phenotype. Therefore, the present study confirmed that CCG is a useful tool in the management of outpatients with CRSwNP. CRSwNP is frequently associated with asthma, aspirin intolerance, and allergy comorbidity. High-grade CCG is frequently characterized by a mixed cytological phenotype, thus, by more severe progress. These real-world outcomes underline that CRSwNP deserves adequate attention for careful management and optimal identification of the best-tailored therapy; CCG and cytological phenotyping could be fruitful tools in clinical practice. Asthma and aspirin intolerance should be adequately investigated in all CRS patients.

Clinical-cytological-grading and phenotyping in patients with chronic rhinosinusitis with nasal polyps: the relevance in clinical practice / M., Gelardi; G., Porro; V., Quaranta; N., Quaranta; M., Cassano; G., Ciprandi; Alonzi, Luigi; Arnone Caruso, Arturo; Barbara, Francesco; Barbara, Michele; Castelnuovo, Paolo; Ciancio, Giovanna; Ciofalo, Andrea; Curatolo, Michele; De Candia, Nicola; De Luca, Carlo; De Robertis, Valentina; Di Benedetto, Valentina; Fiore, Valeria; Iannuzzi, Lucia; Imperatore, Clara; Lingua, Cristiano; Lombardo, Giuseppe; Macchi, Alberto; Mancini, Michela; Maselli del Giudice, Alessandro; Mola, Patrizia; Notargiacomo, Mario; Palma, Antonio; Pecoraro, Piero; Pellitteri, Giuseppe; Piccininni, Krizia; Rinaldi, Massimo; Rossi. Study Group On CRSwNP I., Valentina. - In: MONALDI ARCHIVES FOR CHEST DISEASE. - ISSN 1122-0643. - 90:2(2020), pp. 348-352. [10.4081/monaldi.2020.1277]

Clinical-cytological-grading and phenotyping in patients with chronic rhinosinusitis with nasal polyps: the relevance in clinical practice

Andrea Ciofalo
Investigation
;
2020

Abstract

Chronic rhinosinusitis (CRS) includes two main phenotypes: without nasal polyps (CRSsNP) and with nasal polyps (CRSwNP). CRSwNP may be associated with comorbidity, mainly concerning asthma, aspirin intolerance, and allergy. CRSwNP patients may also be evaluated by clinical-cytological grading (CCG). The current study investigated the prevalence and characteristics of the different CCG and phenotypes in CRSwNP outpatients examined in clinical practice. This retrospective cross-sectional study enrolled 791 consecutive CRSwNP outpatients (424 males, mean age 48.8 years). In the total population, asthma was a common comorbidity (30.8%) as well as aspirin intolerance (24.8%), and allergy (50.8%). As concerns CCG-grading, 210 (26.5%) outpatients had low-grade, 366 (46.3%) medium, and 215 (27.2%) high. As regards cytological phenotypes, 87 (11%) had neutrophilic type, 371 (46.3%) eosinophilic, 112 (14.2%) mast cell, and 221 (27.9%) mixed. High-grade CCG was significantly associated with more frequent asthma, aspirin intolerance, allergy, recurrent surgery, and mixed cytological phenotype. Low-grade CCG was characterized by fewer comorbidities and operations, and neutrophilic phenotype. Therefore, the present study confirmed that CCG is a useful tool in the management of outpatients with CRSwNP. CRSwNP is frequently associated with asthma, aspirin intolerance, and allergy comorbidity. High-grade CCG is frequently characterized by a mixed cytological phenotype, thus, by more severe progress. These real-world outcomes underline that CRSwNP deserves adequate attention for careful management and optimal identification of the best-tailored therapy; CCG and cytological phenotyping could be fruitful tools in clinical practice. Asthma and aspirin intolerance should be adequately investigated in all CRS patients.
2020
chronic rhinosinusitis with nasal polyps; asthma; clinical-cytological-grading; cytological phenotype; comorbidity; real-world
01 Pubblicazione su rivista::01a Articolo in rivista
Clinical-cytological-grading and phenotyping in patients with chronic rhinosinusitis with nasal polyps: the relevance in clinical practice / M., Gelardi; G., Porro; V., Quaranta; N., Quaranta; M., Cassano; G., Ciprandi; Alonzi, Luigi; Arnone Caruso, Arturo; Barbara, Francesco; Barbara, Michele; Castelnuovo, Paolo; Ciancio, Giovanna; Ciofalo, Andrea; Curatolo, Michele; De Candia, Nicola; De Luca, Carlo; De Robertis, Valentina; Di Benedetto, Valentina; Fiore, Valeria; Iannuzzi, Lucia; Imperatore, Clara; Lingua, Cristiano; Lombardo, Giuseppe; Macchi, Alberto; Mancini, Michela; Maselli del Giudice, Alessandro; Mola, Patrizia; Notargiacomo, Mario; Palma, Antonio; Pecoraro, Piero; Pellitteri, Giuseppe; Piccininni, Krizia; Rinaldi, Massimo; Rossi. Study Group On CRSwNP I., Valentina. - In: MONALDI ARCHIVES FOR CHEST DISEASE. - ISSN 1122-0643. - 90:2(2020), pp. 348-352. [10.4081/monaldi.2020.1277]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1434925
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