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EnglishEvery season, circulating influenza viruses change; therefore, vaccines must be reformulated each year. We aimed to estimate vaccine effectiveness (VE) against severe influenza infection for the 2018/19 season in Italy. We conducted a test-negative design case-control study at five Italian hospitals. We estimated influenza VE against severe acute respiratory infection (SARI) requiring hospitalisation overall, and by virus subtype, vaccine brand, and age. The 2018/19 season was characterised by A(H1N1)pmd09 and A(H3N2) influenza viruses. Vaccine coverage among <18 years recruited SARI cases was very low (3.2%). Seasonal vaccines were moderately effective against type A influenza overall (adjusted VE = 40.5%; 95% confidence interval (CI) = 18.7-56.4%) and subtype A(H1N1)pmd09 viruses (adjusted VE = 55%; 95% CI = 34.5-69.1%), but ineffective against subtype A(H3N2) viruses (adjusted VE = 2.5%; 95% CI = -50.0-36.7%). Both Fluad and Fluarix Tetra vaccines were effective against type A influenza overall and subtype A(H1N1)pdm09 viruses. VE appeared to be similar across age groups (0-64 years, ≥65 years). Seasonal influenza vaccines in the 2018/19 season were moderately effective in preventing SARI caused by A(H1N1)pdm09 influenza but ineffective against A(H3N2).
Moderate vaccine effectiveness against severe acute respiratory infection caused by A(H1N1)pdm09 influenza virus and no effectiveness against A(H3N2) influenza virus in the 2018/2019 season in Italy / Rizzo, Caterina; Gesualdo, Francesco; Loconsole, Daniela; Pandolfi, Elisabetta; Bella, Antonino; Orsi, Andrea; Guarona, Giulia; Panatto, Donatella; Icardi, Giancarlo; Napoli, Christian; Orsi, Giovanni Battista; Manini, Ilaria; Montomoli, Emanuele; Campagna, Ilaria; Russo, Luisa; Alfonsi, Valeria; Puzelli, Simona; Reale, Antonino; Raucci, Umberto; Piccioni, Livia; Concato, Carlo; Ciofi Degli Atti, Marta Luisa; Villani, Alberto; Chironna, Maria; Tozzi, Alberto Eugenio. - In: VACCINES. - ISSN 2076-393X. - 8:3(2020), pp. 1-10. [10.3390/vaccines8030427]
| Titolo: | Moderate vaccine effectiveness against severe acute respiratory infection caused by A(H1N1)pdm09 influenza virus and no effectiveness against A(H3N2) influenza virus in the 2018/2019 season in Italy | |
| Autori: | ||
| Data di pubblicazione: | 2020 | |
| Rivista: | ||
| Citazione: | Moderate vaccine effectiveness against severe acute respiratory infection caused by A(H1N1)pdm09 influenza virus and no effectiveness against A(H3N2) influenza virus in the 2018/2019 season in Italy / Rizzo, Caterina; Gesualdo, Francesco; Loconsole, Daniela; Pandolfi, Elisabetta; Bella, Antonino; Orsi, Andrea; Guarona, Giulia; Panatto, Donatella; Icardi, Giancarlo; Napoli, Christian; Orsi, Giovanni Battista; Manini, Ilaria; Montomoli, Emanuele; Campagna, Ilaria; Russo, Luisa; Alfonsi, Valeria; Puzelli, Simona; Reale, Antonino; Raucci, Umberto; Piccioni, Livia; Concato, Carlo; Ciofi Degli Atti, Marta Luisa; Villani, Alberto; Chironna, Maria; Tozzi, Alberto Eugenio. - In: VACCINES. - ISSN 2076-393X. - 8:3(2020), pp. 1-10. [10.3390/vaccines8030427] | |
| Handle: | http://hdl.handle.net/11573/1434219 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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