Nox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it is unknown if this occurs in coronavirus 2019(Covid-19). Nox2 activation by soluble Nox2-derived peptide(sNox2-dp) was measured in patients hospitalized for Covid-19 (n ¼182) and controls (n ¼91). sNox2-dp values were higher in Covid-19 patients versus controls and in severe versus non severe Covid-19. Patients with thrombotic events(n ¼35,19%) had higher sNox2-dp than thrombotic event-free ones. A logistic regression analysis showed that sNox2 and coronary heart disease predicted thrombotic events. Oxidative stress by Nox2 activation is associated severe disease and thrombotic events in Covid-19 patients.
Nox2 activation in covid-19 / Violi, F; Oliva, A; Cangemi, R; Ceccarelli, G; Pignatelli, P; Carnevale, R; Cammisotto, V; Lichtner, M; Alessandri, F; De Angelis, M; Miele, Mc; D'Ettorre, G; Ruberto, F; Venditti, M; Pugliese, F; Mastroianni, Cm.. - In: REDOX BIOLOGY. - ISSN 2213-2317. - 36:(2020). [10.1016/j.redox.2020.101655]
Titolo: | Nox2 activation in covid-19 | |
Autori: | MASTROIANNI, Claudio Maria (Ultimo) | |
Data di pubblicazione: | 2020 | |
Rivista: | ||
Citazione: | Nox2 activation in covid-19 / Violi, F; Oliva, A; Cangemi, R; Ceccarelli, G; Pignatelli, P; Carnevale, R; Cammisotto, V; Lichtner, M; Alessandri, F; De Angelis, M; Miele, Mc; D'Ettorre, G; Ruberto, F; Venditti, M; Pugliese, F; Mastroianni, Cm.. - In: REDOX BIOLOGY. - ISSN 2213-2317. - 36:(2020). [10.1016/j.redox.2020.101655] | |
Handle: | http://hdl.handle.net/11573/1434007 | |
Appartiene alla tipologia: | 01a Articolo in rivista |
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