Nox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it is unknown if this occurs in coronavirus 2019(Covid-19). Nox2 activation by soluble Nox2-derived peptide(sNox2-dp) was measured in patients hospitalized for Covid-19 (n ¼182) and controls (n ¼91). sNox2-dp values were higher in Covid-19 patients versus controls and in severe versus non severe Covid-19. Patients with thrombotic events(n ¼35,19%) had higher sNox2-dp than thrombotic event-free ones. A logistic regression analysis showed that sNox2 and coronary heart disease predicted thrombotic events. Oxidative stress by Nox2 activation is associated severe disease and thrombotic events in Covid-19 patients.

Nox2 activation in covid-19 / Violi, F; Oliva, A; Cangemi, R; Ceccarelli, G; Pignatelli, P; Carnevale, R; Cammisotto, V; Lichtner, M; Alessandri, F; De Angelis, M; Miele, Mc; D'Ettorre, G; Ruberto, F; Venditti, M; Pugliese, F; Mastroianni, Cm.. - In: REDOX BIOLOGY. - ISSN 2213-2317. - 36:(2020). [10.1016/j.redox.2020.101655]

Nox2 activation in covid-19

Violi F
Primo
;
Oliva A;Cangemi R;Ceccarelli G;Pignatelli P;Carnevale R;Cammisotto V;Lichtner M;Alessandri F;De Angelis M;Miele MC;D'Ettorre G;Ruberto F;Venditti M;Pugliese F;Mastroianni CM.
Ultimo
2020

Abstract

Nox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it is unknown if this occurs in coronavirus 2019(Covid-19). Nox2 activation by soluble Nox2-derived peptide(sNox2-dp) was measured in patients hospitalized for Covid-19 (n ¼182) and controls (n ¼91). sNox2-dp values were higher in Covid-19 patients versus controls and in severe versus non severe Covid-19. Patients with thrombotic events(n ¼35,19%) had higher sNox2-dp than thrombotic event-free ones. A logistic regression analysis showed that sNox2 and coronary heart disease predicted thrombotic events. Oxidative stress by Nox2 activation is associated severe disease and thrombotic events in Covid-19 patients.
2020
covid-19; nox-2; NADPH oxidase; thrombosis
01 Pubblicazione su rivista::01a Articolo in rivista
Nox2 activation in covid-19 / Violi, F; Oliva, A; Cangemi, R; Ceccarelli, G; Pignatelli, P; Carnevale, R; Cammisotto, V; Lichtner, M; Alessandri, F; De Angelis, M; Miele, Mc; D'Ettorre, G; Ruberto, F; Venditti, M; Pugliese, F; Mastroianni, Cm.. - In: REDOX BIOLOGY. - ISSN 2213-2317. - 36:(2020). [10.1016/j.redox.2020.101655]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1434007
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