Acute decompensation (AD) of cirrhosis is defined by the acute development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination of these, requiring hospitalization. The presence of organ failure(s) in patients with AD defines acute-on-chronic liver failure (ACLF), while their absence defines AD. We designed the PREDICT study, a European, prospective, observational study, to characterize the clinical course of AD and predict ACLF.

The PREDICT study uncovers three clinical courses in acutely decompensated cirrhosis with distinct pathophysiology / Trebicka, Jonel; Fernandez, Javier; Papp, Maria; Caraceni, Paolo; Laleman, Wim; Gambino, Carmine; Giovo, Ilaria; Uschner, Frank Erhard; Jimenez, Cesar; Mookerjee, Rajeshwar; Gustot, Thierry; Albillos, Agustin; Bañares, Rafael; Janicko, Martin; Steib, Christian; Reiberger, Thomas; Acevedo, Juan; Gatti, Pietro; Bernal, William; Zeuzem, Stefan; Zipprich, Alexander; Piano, Salvatore; Berg, Thomas; Bruns, Tony; Bendtsen, Flemming; Coenraad, Minneke; Merli, Manuela; Stauber, Rudolf; Zoller, Heinz; Ramos, José Presa; Solé, Cristina; Soriano, Germán; de Gottardi, Andrea; Gronbaek, Henning; Saliba, Faouzi; Trautwein, Christian; Özdogan, Osman Cavit; Francque, Sven; Ryder, Stephen; Nahon, Pierre; Romero-Gomez, Manuel; Van Vlierberghe, Hans; Francoz, Claire; Manns, Michael; Garcia, Elisabet; Tufoni, Manuel; Amoros, Alex; Pavesi, Marco; Sanchez, Cristina; Curto, Anna; Pitarch, Carla; Putignano, Antonella; Moreno, Esau; Shawcross, Debbie; Aguilar, Ferran; Claria, Joan; Ponzo, Paola; Jansen, Christian; Vitalis, Zsuzsanna; Zaccherini, Giacomo; Balogh, Boglarka; Vargas, Victor; Montagnese, Sara; Alessandria, Carlo; Bernardi, Mauro; Ginès, Pere; Jalan, Rajiv; Moreau, Richard; Angeli, Paolo; Arroyo, Vicente. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - (2020). [10.1016/j.jhep.2020.06.013]

The PREDICT study uncovers three clinical courses in acutely decompensated cirrhosis with distinct pathophysiology

Merli, Manuela
Membro del Collaboration Group
;
2020

Abstract

Acute decompensation (AD) of cirrhosis is defined by the acute development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination of these, requiring hospitalization. The presence of organ failure(s) in patients with AD defines acute-on-chronic liver failure (ACLF), while their absence defines AD. We designed the PREDICT study, a European, prospective, observational study, to characterize the clinical course of AD and predict ACLF.
2020
Chronic liver disease; Non-elective admission; Outcome; Risk factors; acute complications
01 Pubblicazione su rivista::01a Articolo in rivista
The PREDICT study uncovers three clinical courses in acutely decompensated cirrhosis with distinct pathophysiology / Trebicka, Jonel; Fernandez, Javier; Papp, Maria; Caraceni, Paolo; Laleman, Wim; Gambino, Carmine; Giovo, Ilaria; Uschner, Frank Erhard; Jimenez, Cesar; Mookerjee, Rajeshwar; Gustot, Thierry; Albillos, Agustin; Bañares, Rafael; Janicko, Martin; Steib, Christian; Reiberger, Thomas; Acevedo, Juan; Gatti, Pietro; Bernal, William; Zeuzem, Stefan; Zipprich, Alexander; Piano, Salvatore; Berg, Thomas; Bruns, Tony; Bendtsen, Flemming; Coenraad, Minneke; Merli, Manuela; Stauber, Rudolf; Zoller, Heinz; Ramos, José Presa; Solé, Cristina; Soriano, Germán; de Gottardi, Andrea; Gronbaek, Henning; Saliba, Faouzi; Trautwein, Christian; Özdogan, Osman Cavit; Francque, Sven; Ryder, Stephen; Nahon, Pierre; Romero-Gomez, Manuel; Van Vlierberghe, Hans; Francoz, Claire; Manns, Michael; Garcia, Elisabet; Tufoni, Manuel; Amoros, Alex; Pavesi, Marco; Sanchez, Cristina; Curto, Anna; Pitarch, Carla; Putignano, Antonella; Moreno, Esau; Shawcross, Debbie; Aguilar, Ferran; Claria, Joan; Ponzo, Paola; Jansen, Christian; Vitalis, Zsuzsanna; Zaccherini, Giacomo; Balogh, Boglarka; Vargas, Victor; Montagnese, Sara; Alessandria, Carlo; Bernardi, Mauro; Ginès, Pere; Jalan, Rajiv; Moreau, Richard; Angeli, Paolo; Arroyo, Vicente. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - (2020). [10.1016/j.jhep.2020.06.013]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1431527
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