The PREDICT study uncovers three clinical courses in acutely decompensated cirrhosis with distinct pathophysiology

Acute decompensation (AD) of cirrhosis is defined by the acute development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination of these, requiring hospitalization. The presence of organ failure(s) in patients with AD defines acute-on-chronic liver failure (ACLF), while their absence defines AD. We designed the PREDICT study, a European, prospective, observational study, to characterize the clinical course of AD and predict ACLF.

The PREDICT study uncovers three clinical courses in acutely decompensated cirrhosis with distinct pathophysiology / Trebicka, Jonel; Fernandez, Javier; Papp, Maria; Caraceni, Paolo; Laleman, Wim; Gambino, Carmine; Giovo, Ilaria; Uschner, Frank Erhard; Jimenez, Cesar; Mookerjee, Rajeshwar; Gustot, Thierry; Albillos, Agustin; Bañares, Rafael; Janicko, Martin; Steib, Christian; Reiberger, Thomas; Acevedo, Juan; Gatti, Pietro; Bernal, William; Zeuzem, Stefan; Zipprich, Alexander; Piano, Salvatore; Berg, Thomas; Bruns, Tony; Bendtsen, Flemming; Coenraad, Minneke; Merli, Manuela; Stauber, Rudolf; Zoller, Heinz; Ramos, José Presa; Solé, Cristina; Soriano, Germán; de Gottardi, Andrea; Gronbaek, Henning; Saliba, Faouzi; Trautwein, Christian; Özdogan, Osman Cavit; Francque, Sven; Ryder, Stephen; Nahon, Pierre; Romero-Gomez, Manuel; Van Vlierberghe, Hans; Francoz, Claire; Manns, Michael; Garcia, Elisabet; Tufoni, Manuel; Amoros, Alex; Pavesi, Marco; Sanchez, Cristina; Curto, Anna; Pitarch, Carla; Putignano, Antonella; Moreno, Esau; Shawcross, Debbie; Aguilar, Ferran; Claria, Joan; Ponzo, Paola; Jansen, Christian; Vitalis, Zsuzsanna; Zaccherini, Giacomo; Balogh, Boglarka; Vargas, Victor; Montagnese, Sara; Alessandria, Carlo; Bernardi, Mauro; Ginès, Pere; Jalan, Rajiv; Moreau, Richard; Angeli, Paolo; Arroyo, Vicente. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - (2020). [10.1016/j.jhep.2020.06.013]

Titolo: The PREDICT study uncovers three clinical courses in acutely decompensated cirrhosis with distinct pathophysiology
Autori: 
MERLI, Manuela
mostra contributor esterni 
Data di pubblicazione: 2020
Rivista: 
JOURNAL OF HEPATOLOGY  
Citazione: The PREDICT study uncovers three clinical courses in acutely decompensated cirrhosis with distinct pathophysiology / Trebicka, Jonel; Fernandez, Javier; Papp, Maria; Caraceni, Paolo; Laleman, Wim; Gambino, Carmine; Giovo, Ilaria; Uschner, Frank Erhard; Jimenez, Cesar; Mookerjee, Rajeshwar; Gustot, Thierry; Albillos, Agustin; Bañares, Rafael; Janicko, Martin; Steib, Christian; Reiberger, Thomas; Acevedo, Juan; Gatti, Pietro; Bernal, William; Zeuzem, Stefan; Zipprich, Alexander; Piano, Salvatore; Berg, Thomas; Bruns, Tony; Bendtsen, Flemming; Coenraad, Minneke; Merli, Manuela; Stauber, Rudolf; Zoller, Heinz; Ramos, José Presa; Solé, Cristina; Soriano, Germán; de Gottardi, Andrea; Gronbaek, Henning; Saliba, Faouzi; Trautwein, Christian; Özdogan, Osman Cavit; Francque, Sven; Ryder, Stephen; Nahon, Pierre; Romero-Gomez, Manuel; Van Vlierberghe, Hans; Francoz, Claire; Manns, Michael; Garcia, Elisabet; Tufoni, Manuel; Amoros, Alex; Pavesi, Marco; Sanchez, Cristina; Curto, Anna; Pitarch, Carla; Putignano, Antonella; Moreno, Esau; Shawcross, Debbie; Aguilar, Ferran; Claria, Joan; Ponzo, Paola; Jansen, Christian; Vitalis, Zsuzsanna; Zaccherini, Giacomo; Balogh, Boglarka; Vargas, Victor; Montagnese, Sara; Alessandria, Carlo; Bernardi, Mauro; Ginès, Pere; Jalan, Rajiv; Moreau, Richard; Angeli, Paolo; Arroyo, Vicente. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - (2020). [10.1016/j.jhep.2020.06.013]
Abstract: Acute decompensation (AD) of cirrhosis is defined by the acute development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination of these, requiring hospitalization. The presence of organ failure(s) in patients with AD defines acute-on-chronic liver failure (ACLF), while their absence defines AD. We designed the PREDICT study, a European, prospective, observational study, to characterize the clinical course of AD and predict ACLF.
Handle: http://hdl.handle.net/11573/1431527
Appartiene alla tipologia:01a Articolo in rivista

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