Acute decompensation (AD) of cirrhosis is defined by the acute development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination of these, requiring hospitalization. The presence of organ failure(s) in patients with AD defines acute-on-chronic liver failure (ACLF), while their absence defines AD. We designed the PREDICT study, a European, prospective, observational study, to characterize the clinical course of AD and predict ACLF.
The PREDICT study uncovers three clinical courses in acutely decompensated cirrhosis with distinct pathophysiology / Trebicka, Jonel; Fernandez, Javier; Papp, Maria; Caraceni, Paolo; Laleman, Wim; Gambino, Carmine; Giovo, Ilaria; Uschner, Frank Erhard; Jimenez, Cesar; Mookerjee, Rajeshwar; Gustot, Thierry; Albillos, Agustin; Bañares, Rafael; Janicko, Martin; Steib, Christian; Reiberger, Thomas; Acevedo, Juan; Gatti, Pietro; Bernal, William; Zeuzem, Stefan; Zipprich, Alexander; Piano, Salvatore; Berg, Thomas; Bruns, Tony; Bendtsen, Flemming; Coenraad, Minneke; Merli, Manuela; Stauber, Rudolf; Zoller, Heinz; Ramos, José Presa; Solé, Cristina; Soriano, Germán; de Gottardi, Andrea; Gronbaek, Henning; Saliba, Faouzi; Trautwein, Christian; Özdogan, Osman Cavit; Francque, Sven; Ryder, Stephen; Nahon, Pierre; Romero-Gomez, Manuel; Van Vlierberghe, Hans; Francoz, Claire; Manns, Michael; Garcia, Elisabet; Tufoni, Manuel; Amoros, Alex; Pavesi, Marco; Sanchez, Cristina; Curto, Anna; Pitarch, Carla; Putignano, Antonella; Moreno, Esau; Shawcross, Debbie; Aguilar, Ferran; Claria, Joan; Ponzo, Paola; Jansen, Christian; Vitalis, Zsuzsanna; Zaccherini, Giacomo; Balogh, Boglarka; Vargas, Victor; Montagnese, Sara; Alessandria, Carlo; Bernardi, Mauro; Ginès, Pere; Jalan, Rajiv; Moreau, Richard; Angeli, Paolo; Arroyo, Vicente. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - (2020). [10.1016/j.jhep.2020.06.013]
The PREDICT study uncovers three clinical courses in acutely decompensated cirrhosis with distinct pathophysiology
Merli, ManuelaMembro del Collaboration Group
;
2020
Abstract
Acute decompensation (AD) of cirrhosis is defined by the acute development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination of these, requiring hospitalization. The presence of organ failure(s) in patients with AD defines acute-on-chronic liver failure (ACLF), while their absence defines AD. We designed the PREDICT study, a European, prospective, observational study, to characterize the clinical course of AD and predict ACLF.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
