Sex hormones and inflammation role in oral cancer progression. A molecular and biological point of view

Oral cancers have been proven to arise from precursors lesions and related to risk behaviour such as alcohol consumption and smoke. However, the present paper focus on the role of chronic inflammation, related with chronical oral infections and/or altered immune responses occurring during dysimmune and autoimmune diseases, in the oral cancerogenesis. Particularly, oral candidiasis and periodontal diseases, introduce a vicious circle of non-healing and perpetuation of the inflammatory processes, thus leading towards cancer occurrence, via local and systemic inflammatory modulators and via genetic and epigenetic factors.