The immune checkpoint inhibitors, a class of drugs able to block immune suppressive pathways in order to prime an anticancer immunity, revolutionized standard of care in platinum-refractory recurrent and/or metastatic head and neck carcinoma (R/M HNSCC). The PD-1/ PD-L1 axis is involved in the genesis, maintenance and progression of HNSCC and represents the target of checkpoint inhibitors. HNSCC is an immunosuppressive disease with a high inflammatory component in tumor microenvironment. Recent clinical trials showed that only a small subset of patients really benefits from immunotherapy. This review aims to highlight the five W-points of immunotherapy: why immunotherapy is promising in HNSCC, what is currently available in daily clinical practice, when immunotherapy can be integrated into the therapeutic strategy, where it can be useful according to predictive response biomarker, who, among patients, could get the best benefit from immunotherapy and how improve the achieved results.

The 5-Ws of immunotherapy in head and neck cancer / Botticelli, Andrea; Mezi, Silvia; Pomati, Giulia; Cerbelli, Bruna; Di Rocco, Christiana; Amirhassankhani, Sasan; Sirgiovanni, Grazia; Occhipinti, Mario; Napoli, Valerio; Emiliani, Alessandra; Mazzuca, Federica; Tomao, Silverio; Nuti, Marianna; Marchetti, Paolo. - In: CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY. - ISSN 1879-0461. - 153:(2020). [10.1016/j.critrevonc.2020.103041]

The 5-Ws of immunotherapy in head and neck cancer

Botticelli, Andrea
Co-primo
;
Mezi, Silvia
Co-primo
;
Pomati, Giulia
Secondo
;
Cerbelli, Bruna;Di Rocco, Christiana;Sirgiovanni, Grazia;Occhipinti, Mario;Napoli, Valerio;Emiliani, Alessandra;Mazzuca, Federica;Tomao, Silverio;Nuti, Marianna
Penultimo
;
Marchetti, Paolo
Ultimo
2020

Abstract

The immune checkpoint inhibitors, a class of drugs able to block immune suppressive pathways in order to prime an anticancer immunity, revolutionized standard of care in platinum-refractory recurrent and/or metastatic head and neck carcinoma (R/M HNSCC). The PD-1/ PD-L1 axis is involved in the genesis, maintenance and progression of HNSCC and represents the target of checkpoint inhibitors. HNSCC is an immunosuppressive disease with a high inflammatory component in tumor microenvironment. Recent clinical trials showed that only a small subset of patients really benefits from immunotherapy. This review aims to highlight the five W-points of immunotherapy: why immunotherapy is promising in HNSCC, what is currently available in daily clinical practice, when immunotherapy can be integrated into the therapeutic strategy, where it can be useful according to predictive response biomarker, who, among patients, could get the best benefit from immunotherapy and how improve the achieved results.
2020
head and neck cancer; immune checkpoint inhibitors; immunosuppressive microenvironment; immunotherapy; PD-1/PD-L1 axis
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The 5-Ws of immunotherapy in head and neck cancer / Botticelli, Andrea; Mezi, Silvia; Pomati, Giulia; Cerbelli, Bruna; Di Rocco, Christiana; Amirhassankhani, Sasan; Sirgiovanni, Grazia; Occhipinti, Mario; Napoli, Valerio; Emiliani, Alessandra; Mazzuca, Federica; Tomao, Silverio; Nuti, Marianna; Marchetti, Paolo. - In: CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY. - ISSN 1879-0461. - 153:(2020). [10.1016/j.critrevonc.2020.103041]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1429330
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