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EnglishMicroRNAs (miRs) have emerged as biomarkers of migraine disease in both adults and children. In this study we evaluated the expression of hsa-miR-34a-5p and hsa-miR-375 in serum and saliva of young subjects (age 11 +/- 3.467 years) with migraine without aura (MWA), while some underwent pharmacological treatment, and healthy young subjects were used as controls. miRs were determined using the qRT-PCR method, and gene targets of hsa-miR-34a-5p and hsa-miR-375 linked to pain-migraine were found by in silico analysis. qRT-PCR revealed comparable levels of hsa-miRs in both blood and saliva. Higher expression of hsa-miR-34a-5p and hsa-miR-375 was detected in saliva of untreated MWAs compared to healthy subjects (hsa-miR-34a-5p: p < 0.05; hsa-miR-375 p < 0.01). Furthermore, in MWA treated subjects, a significant decrease of hsa-miR-34a-5p and of hsa-miR-375 was documented in saliva and blood compared to MWA untreated ones. Altogether, these findings suggested thathsa-miR-34a-5p and hsa-miR-375 are expressed equally in blood and saliva and that they could be a useful biomarker of disease and of drug efficacy in patients with MWA.
Hsa-miR-34a-5p and hsa-miR-375 as biomarkers for monitoring the effects of drug treatment for migraine pain in children and adolescents: A Pilot study / Gallelli, L; Cione, E; Peltrone, F; Siviglia, S; Verano, A; Chirchiglia, D; Zampogna, S; Guidetti, V; Sammartino, L; Montana, A; Caroleo, Mc; De Sarro, G; Di Mizio, G. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 8:7(2019), pp. 1-11. [10.3390/jcm8070928]
| Titolo: | Hsa-miR-34a-5p and hsa-miR-375 as biomarkers for monitoring the effects of drug treatment for migraine pain in children and adolescents: A Pilot study | |
| Autori: | DI MIZIO, GIORGIO (Corresponding author) | |
| Data di pubblicazione: | 2019 | |
| Rivista: | ||
| Citazione: | Hsa-miR-34a-5p and hsa-miR-375 as biomarkers for monitoring the effects of drug treatment for migraine pain in children and adolescents: A Pilot study / Gallelli, L; Cione, E; Peltrone, F; Siviglia, S; Verano, A; Chirchiglia, D; Zampogna, S; Guidetti, V; Sammartino, L; Montana, A; Caroleo, Mc; De Sarro, G; Di Mizio, G. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 8:7(2019), pp. 1-11. [10.3390/jcm8070928] | |
| Handle: | http://hdl.handle.net/11573/1429248 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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| Gallelli_Hsa-miR-34a-5p_2019.pdf | Versione editoriale (versione pubblicata con il layout dell'editore) |  | Open Access Visualizza/Apri |
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