Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and YAP plays an essential role in mediating the exacerbation of heart failure in response to pressure overload in the hearts of mice fed a high-fat diet. YAP induced dedifferentiation of cardiomyocytes through activation of transcriptional enhancer factor 1 (TEAD1), a transcription factor. Thus, YAP and TEAD1 are promising therapeutic targets for diabetic patients with high blood pressure to prevent the development of heart failure.

Yes-Associated Protein (YAP) facilitates pressure overload–induced dysfunction in the diabetic heart / Ikeda, S.; Mukai, R.; Mizushima, W.; Zhai, P.; Oka, S. -I.; Nakamura, M.; Del Re, D. P.; Sciarretta, S.; Hsu, C. -P.; Shimokawa, H.; Sadoshima, J.. - In: JACC. BASIC TO TRANSLATIONAL SCIENCE. - ISSN 2452-302X. - 4:5(2019), pp. 611-622. [10.1016/j.jacbts.2019.05.006]

Yes-Associated Protein (YAP) facilitates pressure overload–induced dysfunction in the diabetic heart

Sciarretta S.;
2019

Abstract

Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and YAP plays an essential role in mediating the exacerbation of heart failure in response to pressure overload in the hearts of mice fed a high-fat diet. YAP induced dedifferentiation of cardiomyocytes through activation of transcriptional enhancer factor 1 (TEAD1), a transcription factor. Thus, YAP and TEAD1 are promising therapeutic targets for diabetic patients with high blood pressure to prevent the development of heart failure.
2019
diabetes; diabetic cardiomyopathy; Hippo pathway; pressure overload
01 Pubblicazione su rivista::01a Articolo in rivista
Yes-Associated Protein (YAP) facilitates pressure overload–induced dysfunction in the diabetic heart / Ikeda, S.; Mukai, R.; Mizushima, W.; Zhai, P.; Oka, S. -I.; Nakamura, M.; Del Re, D. P.; Sciarretta, S.; Hsu, C. -P.; Shimokawa, H.; Sadoshima, J.. - In: JACC. BASIC TO TRANSLATIONAL SCIENCE. - ISSN 2452-302X. - 4:5(2019), pp. 611-622. [10.1016/j.jacbts.2019.05.006]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1428943
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