Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.

Comprehensive autophagy evaluation in cardiac disease models / Kaludercic, N.; Maiuri, M. C.; Kaushik, S.; Fernandez, A. F.; De Bruijn, J.; Castoldi, F.; Chen, Y.; Ito, J.; Mukai, R.; Murakawa, T.; Nah, J.; Pietrocola, F.; Saito, T.; Sebti, S.; Semenzato, M.; Tsansizi, L.; Sciarretta, S.; Madrigal-Matute, J.. - In: CARDIOVASCULAR RESEARCH. - ISSN 0008-6363. - 116:3(2020), pp. 483-504. [10.1093/cvr/cvz233]

Comprehensive autophagy evaluation in cardiac disease models

Sciarretta S.;
2020

Abstract

Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.
2020
autophagy; autosis; cardiac diseases; chaperone-mediated autophagy; heart; mitophagy
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Comprehensive autophagy evaluation in cardiac disease models / Kaludercic, N.; Maiuri, M. C.; Kaushik, S.; Fernandez, A. F.; De Bruijn, J.; Castoldi, F.; Chen, Y.; Ito, J.; Mukai, R.; Murakawa, T.; Nah, J.; Pietrocola, F.; Saito, T.; Sebti, S.; Semenzato, M.; Tsansizi, L.; Sciarretta, S.; Madrigal-Matute, J.. - In: CARDIOVASCULAR RESEARCH. - ISSN 0008-6363. - 116:3(2020), pp. 483-504. [10.1093/cvr/cvz233]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1428891
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