Antihypertensive Efficacy of lcz696 in Hypertension

Essential hypertension is a complex clinical condition, characterized by sustained elevation of systolic and/or diastolic blood pressure (BP) levels and an increased risk of developing major cardiovascular (CV) outcomes, mostly including coronary artery disease, stroke, and death. Several studies have also reported that high BP levels are significantly related to AC higher risk of new- onset congestive heart failure than normotension and that hypertensive disease (i.e., left ventricular diastolic dysfunction with or without left ventricular remodeling or hypertrophy) may be responsible of the progression from hypertension toward left ventricular systolic dys- function and clinically evident heart failure, indepen- dently of the presence of concomitant conditions and co- morbidities