Background: Despite the incidence of Frontal fibrosing alopecia (FFA) has been increasing in last two decades, the pathophysiology and trigger factors of FFA have not been yet fully understood. Aims: The aim of this study was to describe epidemiology, clinical and trichoscopic features and comorbidities of FFA patients, in order to improve the understanding of this disease. Patients/methods: A retrospective, observational monocentric study was conducted from 2003 to 2019. Data concerning epidemiology (age, gender, age of menopause and age of FFA onset), comorbidities, current therapies, localization of FFA (such as frontotemporal hairline, occipital, eyebrow, eyelash, beard, sideburns and body hair), presence of papules and sign of Lichen planus (LP) at skin, mucosae and/or nail were collected for each patient included. Results: A total of 119 Caucasian, adult patients (8 men, 111 female) with FFA were enrolled in the study. Cutaneous, mucosal or nail localization of LP were found in 16% of our subjects. Interestingly, 15 out of 119 subjects (10.61%) were affected by concomitant genital Lichen sclerosus (LS) and 5 out of these 15 patients (4.38%) presented both LS and LP in association with FFA CONCLUSION: Considering the high prevalence of LS in FFA patients in our case series, and the frequency of autoimmune comorbidities in both LS and FFA, it is possible to hypothesize an autoimmune process in both conditions. Further studies are needed for a better understanding of the nature of the association between LS and FFA.

Frontal fibrosing alopecia and genital lichen sclerosus: single-center experience / Grassi, Sara; Tadiotto Cicogna, Giulia; Magri, Francesca; Fortuna, MARIA CATERINA; Caro, Gemma; Pernazza, Angelina; Soda, Giuseppe; Miraglia, Emanuele; Giustini, Sandra; Carlesimo, Marta; Rossi, Alfredo. - In: JOURNAL OF COSMETIC DERMATOLOGY. - ISSN 1473-2165. - 20:2(2021), pp. 615-620.

Frontal fibrosing alopecia and genital lichen sclerosus: single-center experience

Sara Grassi
;
Francesca Magri;Maria Caterina Fortuna;Gemma Caro;Angelina Pernazza;Giuseppe Soda;Emanuele Miraglia;Sandra Giustini;Marta Carlesimo;Alfredo Rossi
2021

Abstract

Background: Despite the incidence of Frontal fibrosing alopecia (FFA) has been increasing in last two decades, the pathophysiology and trigger factors of FFA have not been yet fully understood. Aims: The aim of this study was to describe epidemiology, clinical and trichoscopic features and comorbidities of FFA patients, in order to improve the understanding of this disease. Patients/methods: A retrospective, observational monocentric study was conducted from 2003 to 2019. Data concerning epidemiology (age, gender, age of menopause and age of FFA onset), comorbidities, current therapies, localization of FFA (such as frontotemporal hairline, occipital, eyebrow, eyelash, beard, sideburns and body hair), presence of papules and sign of Lichen planus (LP) at skin, mucosae and/or nail were collected for each patient included. Results: A total of 119 Caucasian, adult patients (8 men, 111 female) with FFA were enrolled in the study. Cutaneous, mucosal or nail localization of LP were found in 16% of our subjects. Interestingly, 15 out of 119 subjects (10.61%) were affected by concomitant genital Lichen sclerosus (LS) and 5 out of these 15 patients (4.38%) presented both LS and LP in association with FFA CONCLUSION: Considering the high prevalence of LS in FFA patients in our case series, and the frequency of autoimmune comorbidities in both LS and FFA, it is possible to hypothesize an autoimmune process in both conditions. Further studies are needed for a better understanding of the nature of the association between LS and FFA.
2021
ECM 1; frontal fibrosing alopecia; lichen sclerosus; comorbidities; scarring alopecia; trichoscopy
01 Pubblicazione su rivista::01a Articolo in rivista
Frontal fibrosing alopecia and genital lichen sclerosus: single-center experience / Grassi, Sara; Tadiotto Cicogna, Giulia; Magri, Francesca; Fortuna, MARIA CATERINA; Caro, Gemma; Pernazza, Angelina; Soda, Giuseppe; Miraglia, Emanuele; Giustini, Sandra; Carlesimo, Marta; Rossi, Alfredo. - In: JOURNAL OF COSMETIC DERMATOLOGY. - ISSN 1473-2165. - 20:2(2021), pp. 615-620.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1423012
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