Background: The loco regional relapse is frequent in the lung disease. The aim of this study was to evaluate the outcomes of re-irradiation by SBRT in terms of Local Control (LC) and toxicities. Methods: From April 2011 to December 2016, twenty-two patients received a re-irradiation by SBRT. Twenty- seven lesions were treated. The medium BED(10) of re-irradiation was 100.6 Gy (range: 48-151.2 Gy) and the medium EQD2(10) was 93.8 Gy (range: 40-126 Gy). In the previous treatment the medium BED(10) was 97.2 Gy (range: 40-120 Gy), the medium EQD2(10) was 81 Gy (range: 32.5-100 Gy). The median time between the first and the second treatment was 18 months. Results: Local Control was reached in 18 out of 27 (66%) re-irradiated lesions, with rates of 67 and 54% at 1- year and 2- years respectively. The treatment was well tolerated; the maximum recorded toxicity was Grade 3. Conclusions: Re- irradiation by SBRT may represent an option for the treatment of lung disease with good results in terms of LC and toxicity.
Re-irradiation in lung disease by SBRT. A retrospective, single institutional study / Caivano, D.; Valeriani, M.; De Matteis, S.; Bonome, P.; Russo, I.; De Sanctis, V.; Minniti, G.; Osti, M. F.. - In: RADIATION ONCOLOGY. - ISSN 1748-717X. - 13:1(2018), pp. 1-8. [10.1186/s13014-018-1041-y]
Re-irradiation in lung disease by SBRT. A retrospective, single institutional study
Caivano D.
;De Matteis S.Membro del Collaboration Group
;Bonome P.;De Sanctis V.Membro del Collaboration Group
;Minniti G.;Osti M. F.
2018
Abstract
Background: The loco regional relapse is frequent in the lung disease. The aim of this study was to evaluate the outcomes of re-irradiation by SBRT in terms of Local Control (LC) and toxicities. Methods: From April 2011 to December 2016, twenty-two patients received a re-irradiation by SBRT. Twenty- seven lesions were treated. The medium BED(10) of re-irradiation was 100.6 Gy (range: 48-151.2 Gy) and the medium EQD2(10) was 93.8 Gy (range: 40-126 Gy). In the previous treatment the medium BED(10) was 97.2 Gy (range: 40-120 Gy), the medium EQD2(10) was 81 Gy (range: 32.5-100 Gy). The median time between the first and the second treatment was 18 months. Results: Local Control was reached in 18 out of 27 (66%) re-irradiated lesions, with rates of 67 and 54% at 1- year and 2- years respectively. The treatment was well tolerated; the maximum recorded toxicity was Grade 3. Conclusions: Re- irradiation by SBRT may represent an option for the treatment of lung disease with good results in terms of LC and toxicity.| File | Dimensione | Formato | |
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