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EnglishPurpose: Serous adenocarcinoma (uterine serous carcinoma - USC) is a rare and aggressive histologic subtype of endometrial cancer, with a high-rate of recurrence and poor prognosis. The adjuvant treatment for stage I patients is unclear. The purpose of this study was to evaluate the outcomes of stage I USC treated exclusively with chemotherapy plus vaginal brachytherapy (VBT).Material and methods: A systematic research using PubMed, Scopus, and Cochrane library was conducted to identify full articles evaluating the efficacy of VBT in patients with stage I USC. A search in ClinicalTrials.gov was performed in order to detect ongoing or recently completed trials, and in PROSPERO for searching ongoing or recently completed systematic reviews.Results: All studies were retrospective and 364 of evaluated patients were found. The average local control was 97.5% (range, 91-100%), the disease free-survival was 88% (range, 82-94%), the overall survival was 93% (range, 72-100%), the specific cancer survival was 89.4% (range, 84.8-94%), and the G3-G4 toxicity was 0-8%.Conclusions: These data support the concept that in adequately selected patients, VBT alone may be a suitable radio- therapy technique in women with stage I USC who underwent surgical staging and received adjuvant chemotherapy.
The role of vaginal brachytherapy in stage I endometrial serous cancer. a systematic review / Lancellotta, Valentina; De Felice, Francesca; Vicenzi, Lisa; Antonacci, Alfredo; Cerboneschi, Valentina; Costantini, Sara; di Cristino, Daniela; Tagliaferri, Luca; Cerrotta, Annamaria; Vavassori, Andrea; Gribaudo, Sergio; Colombo, Alessandro; Lucà, Francesco; Barbara, Raffaele; Mangoni, Monica; Marampon, Francesco; Musio, Daniela; Bellati, Filippo; Torcia, Francesco; Tombolini, Vincenzo; Osti, Mattia Falchetto; De Sanctis, Vitaliana. - In: JOURNAL OF CONTEMPORARY BRACHYTHERAPY. - ISSN 1689-832X. - 12:1(2020), pp. 61-66. [10.5114/jcb.2020.92698]
| Titolo: | The role of vaginal brachytherapy in stage I endometrial serous cancer. a systematic review | |
| Autori: | ||
| Data di pubblicazione: | 2020 | |
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| Citazione: | The role of vaginal brachytherapy in stage I endometrial serous cancer. a systematic review / Lancellotta, Valentina; De Felice, Francesca; Vicenzi, Lisa; Antonacci, Alfredo; Cerboneschi, Valentina; Costantini, Sara; di Cristino, Daniela; Tagliaferri, Luca; Cerrotta, Annamaria; Vavassori, Andrea; Gribaudo, Sergio; Colombo, Alessandro; Lucà, Francesco; Barbara, Raffaele; Mangoni, Monica; Marampon, Francesco; Musio, Daniela; Bellati, Filippo; Torcia, Francesco; Tombolini, Vincenzo; Osti, Mattia Falchetto; De Sanctis, Vitaliana. - In: JOURNAL OF CONTEMPORARY BRACHYTHERAPY. - ISSN 1689-832X. - 12:1(2020), pp. 61-66. [10.5114/jcb.2020.92698] | |
| Handle: | http://hdl.handle.net/11573/1420983 | |
| Appartiene alla tipologia: | 01g Articolo di rassegna (Review) |
File allegati a questo prodotto
| File | Note | Tipologia | Licenza | |
|---|---|---|---|---|
| Bellati_Role-of-vaginal.pdf | Versione editoriale (versione pubblicata con il layout dell'editore) |  | Open Access Visualizza/Apri |
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