Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis that is characterized by obstruction of the arteries in the lower limbs. Experimental and epidemiological studies suggested a key role for oxidative stress in initiation and progression of the atherosclerotic process. The results of these studies provided a good basis for interventional trials with antioxidants, particularly with vitamin E, but the findings were conflicting. In this paper we review the observational and interventional studies with antioxidants, and ask whether vitamins supplementation should or should be not be recommended for PAD patients.

Antioxidants in peripheral arterial disease / Violi, Francesco; Loffredo, Lorenzo; A., Marcoccia. - In: CURRENT DRUG TARGETS. - ISSN 1389-4501. - 4:3(2004), pp. 289-294. [10.2174/1568006043336212]

Antioxidants in peripheral arterial disease

VIOLI, Francesco;LOFFREDO, Lorenzo;
2004

Abstract

Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis that is characterized by obstruction of the arteries in the lower limbs. Experimental and epidemiological studies suggested a key role for oxidative stress in initiation and progression of the atherosclerotic process. The results of these studies provided a good basis for interventional trials with antioxidants, particularly with vitamin E, but the findings were conflicting. In this paper we review the observational and interventional studies with antioxidants, and ask whether vitamins supplementation should or should be not be recommended for PAD patients.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/141694
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