Cytochrome bd is a quinol respiratory oxidase widely distributed among bacteria, where its expression favours survival under low O 2 tensions, and in the presence of nitric oxide (NO) produced by the host immune system. NO reacts with and reversibly inhibits the haem-copper terminal oxidases (HCO) where it binds at the active site, containing a haem-iron and a copper (Cu B). NO reacts also similarly with the copper lacking active site of cytochrome bd, a structural peculiarity that allows one to address the question of whether Cu B plays a role in the reaction with NO (and other ligands). In this minireview we discuss the properties of the reactions between bd-type oxidases and NO, and highlight consequences to cell/bacteria physiology.

Cytochrome bd, a key oxidase in bacterial survival and tolerance to nitrosative stress / Forte, Elena; V. B., Borisov; A. A., Konstantinov; Brunori, Maurizio; Giuffre', Alessandro; Sarti, Paolo. - In: ITALIAN JOURNAL OF BIOCHEMISTRY. - ISSN 0021-2938. - 56:4(2007), pp. 265-269.

Cytochrome bd, a key oxidase in bacterial survival and tolerance to nitrosative stress

FORTE, Elena;BRUNORI, Maurizio;GIUFFRE', ALESSANDRO;SARTI, Paolo
2007

Abstract

Cytochrome bd is a quinol respiratory oxidase widely distributed among bacteria, where its expression favours survival under low O 2 tensions, and in the presence of nitric oxide (NO) produced by the host immune system. NO reacts with and reversibly inhibits the haem-copper terminal oxidases (HCO) where it binds at the active site, containing a haem-iron and a copper (Cu B). NO reacts also similarly with the copper lacking active site of cytochrome bd, a structural peculiarity that allows one to address the question of whether Cu B plays a role in the reaction with NO (and other ligands). In this minireview we discuss the properties of the reactions between bd-type oxidases and NO, and highlight consequences to cell/bacteria physiology.
2007
cytochromes; microbiology; nitric oxide; ros
01 Pubblicazione su rivista::01a Articolo in rivista
Cytochrome bd, a key oxidase in bacterial survival and tolerance to nitrosative stress / Forte, Elena; V. B., Borisov; A. A., Konstantinov; Brunori, Maurizio; Giuffre', Alessandro; Sarti, Paolo. - In: ITALIAN JOURNAL OF BIOCHEMISTRY. - ISSN 0021-2938. - 56:4(2007), pp. 265-269.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/141571
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