The invention provides a method for producing therapeutic cannabinoids characterized by administering to an host the probiotic Lactobacillus Paracasei subsp. Paracasei F19, genetically modified to produce and secrete cannabinoids from Cannabis sativa, in association with caproic acid, able to establish the enzymatic reactions of the biosynthetic pathway leading to the production of cannabinoids directly in situ in said host.
BIOLOGICAL COMPOSITION BASED ON ENGINEERED LACTOBACILLUS PARACASEI SUBSP. PARACASEI F19 FOR THE BIOSYNTHESIS OF CANNABINOIDS / Sannetti, Augusto; Cuomo, Rosario; Sarnelli, Giovanni; Esposito, Giuseppe; Lu, Jie. - (2016).