Background: Actinic keratosis (AK) is a common keratinocyte intraepidermal neoplasia. Objective: To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics. Materials & methods: This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented. Results: AK prevalence in 7,284 patients was 27.4% (95% CI: 26.4-28.4%); 34.3% in men and 20.0% in women (p<0.001). Independent AK risk factors in 4,604 patients were: age (OR: 4.8 [95% CI: 3.5-6.5] for 46-60 years, increasing with older age to OR: 41.5 [95% CI: 29.5-58.2] for >70 years), history of other non-melanoma skin cancers (OR: 2.7 [2.2-3.3]), residence in southern Italy/Sardinia (OR: 2.6 [2.1-3.0]), working outdoors >6 hours/day (OR: 1.9 [1.4-2.4]), male gender (OR: 1.7 [1.4-2.0]), facial solar lentigos (OR: 1.6 [1.4-1.9]), light hair colour (OR: 1.5 [1.2-1.8]), prolonged outdoor recreational activities (OR: 1.4 [1.2-1.7]), light eye colour (OR: 1.3 [1.1-1.6]), skin type I/II (OR: 1.3 [1.1-1.6]), and alcohol consumption (OR: 1.2 [1.0-3.3]). BMI ≥25.0 (OR: 0.6 [0.5-0.7]), regular sunscreen use (OR: 0.7 [0.6-0.8]), and a lower level of education (OR: 0.8 [0.7-1.0]) were independent protective factors. Conclusions: AK prevalence was high in Italian dermatology outpatients. We confirm several well-known AK risk factors and reveal possible novel risk and protective factors. Our results may inform on the design and implementation of AK screening and educational programmes.

Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics / Fargnoli, M. C.; Altomare, G.; Benati, E.; Borgia, F.; Broganelli, P.; Carbone, A.; Chimenti, Sergio; Donato, S.; Girolomoni, G.; Micali, G.; Moggio, E.; Parodi, A.; Piaserico, S.; Pistone, G.; Potenza, C.; Puviani, M.; Raucci, M.; Vaccari, S.; Veglio, S.; Zanca, A.; Peris, K.. - In: EUROPEAN JOURNAL OF DERMATOLOGY. - ISSN 1167-1122. - 27:6(2017), pp. 599-608. [10.1684/ejd.2017.3126]

Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics

Potenza C.;
2017

Abstract

Background: Actinic keratosis (AK) is a common keratinocyte intraepidermal neoplasia. Objective: To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics. Materials & methods: This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented. Results: AK prevalence in 7,284 patients was 27.4% (95% CI: 26.4-28.4%); 34.3% in men and 20.0% in women (p<0.001). Independent AK risk factors in 4,604 patients were: age (OR: 4.8 [95% CI: 3.5-6.5] for 46-60 years, increasing with older age to OR: 41.5 [95% CI: 29.5-58.2] for >70 years), history of other non-melanoma skin cancers (OR: 2.7 [2.2-3.3]), residence in southern Italy/Sardinia (OR: 2.6 [2.1-3.0]), working outdoors >6 hours/day (OR: 1.9 [1.4-2.4]), male gender (OR: 1.7 [1.4-2.0]), facial solar lentigos (OR: 1.6 [1.4-1.9]), light hair colour (OR: 1.5 [1.2-1.8]), prolonged outdoor recreational activities (OR: 1.4 [1.2-1.7]), light eye colour (OR: 1.3 [1.1-1.6]), skin type I/II (OR: 1.3 [1.1-1.6]), and alcohol consumption (OR: 1.2 [1.0-3.3]). BMI ≥25.0 (OR: 0.6 [0.5-0.7]), regular sunscreen use (OR: 0.7 [0.6-0.8]), and a lower level of education (OR: 0.8 [0.7-1.0]) were independent protective factors. Conclusions: AK prevalence was high in Italian dermatology outpatients. We confirm several well-known AK risk factors and reveal possible novel risk and protective factors. Our results may inform on the design and implementation of AK screening and educational programmes.
2017
actinic keratosis; Italy; prevalence; risk factors; adult; aged; ambulatory care facilities; dermatology; european continental ancestry group; female; humans; keratosis, actinic; male; middle aged; prevalence; retrospective studies; risk factors; skin neoplasms
01 Pubblicazione su rivista::01a Articolo in rivista
Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics / Fargnoli, M. C.; Altomare, G.; Benati, E.; Borgia, F.; Broganelli, P.; Carbone, A.; Chimenti, Sergio; Donato, S.; Girolomoni, G.; Micali, G.; Moggio, E.; Parodi, A.; Piaserico, S.; Pistone, G.; Potenza, C.; Puviani, M.; Raucci, M.; Vaccari, S.; Veglio, S.; Zanca, A.; Peris, K.. - In: EUROPEAN JOURNAL OF DERMATOLOGY. - ISSN 1167-1122. - 27:6(2017), pp. 599-608. [10.1684/ejd.2017.3126]
File allegati a questo prodotto
File Dimensione Formato  
Fargnoli_Prevalence-risk-factors_2017.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.23 MB
Formato Adobe PDF
1.23 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1415034
Citazioni
  • ???jsp.display-item.citation.pmc??? 11
  • Scopus 32
  • ???jsp.display-item.citation.isi??? 0
social impact