Meningoencephalitis is the most common neurological complication related to Epstein-Barr virus (EBV), and in immunocompetent adults, it is most commonly self-limited. We describe a case of fatal EBV infection characterized by meningoencephalitis, foci of myocarditis and interstitial nephritis in an immunocompetent 74-year-old man. The postmortem diagnosis was made based on the presence of EBV DNA in the cerebrospinal fluid and by immunohistochemical assay that showed spots of intracellular positivity to anti-EBV antibody in brain tissue.
Fatal Epstein-Barr virus infection in an immunocompetent host: a postmortem diagnosis / Maiese, A.; La Russa, R.; Passaro, G.; Santoro, P.; De Matteis, A.; Fineschi, V.. - In: FORENSIC SCIENCE, MEDICINE AND PATHOLOGY. - ISSN 1547-769X. - (2020). [10.1007/s12024-020-00254-z]
Fatal Epstein-Barr virus infection in an immunocompetent host: a postmortem diagnosis
Maiese A.;La Russa R.;Santoro P.;De Matteis A.;Fineschi V.
2020
Abstract
Meningoencephalitis is the most common neurological complication related to Epstein-Barr virus (EBV), and in immunocompetent adults, it is most commonly self-limited. We describe a case of fatal EBV infection characterized by meningoencephalitis, foci of myocarditis and interstitial nephritis in an immunocompetent 74-year-old man. The postmortem diagnosis was made based on the presence of EBV DNA in the cerebrospinal fluid and by immunohistochemical assay that showed spots of intracellular positivity to anti-EBV antibody in brain tissue.| File | Dimensione | Formato | |
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