Src is the representative member of the Src-family kinases (SFKs), a group of tyrosine kinases involved in several cellular processes. Its main function has been for long confined to the plasma membrane/cytoplasm compartment, being a myristoylated protein anchored to the cell membrane and functioning downstream to receptors, most of them lacking intrinsic kinase activity. In the last decades, new roles for some SFKs have been described in the nuclear compartment, suggesting that these proteins can also be involved in directly regulating gene transcription or nucleoskeleton architecture. In this review, we focused on those nuclear functions specifically attributable to Src, by considering its function as both tyrosine kinase and adapting molecule. In particular, we addressed the Src involvement in physiological as well as in pathological conditions, especially in tumors.

Nuclear functions of the tyrosine kinase Src / Bagnato, G.; Leopizzi, M.; Urciuoli, E.; Peruzzi, B.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 21:8(2020), pp. 1-14. [10.3390/ijms21082675]

Nuclear functions of the tyrosine kinase Src

Leopizzi M.
Co-primo
;
Urciuoli E.
Penultimo
;
2020

Abstract

Src is the representative member of the Src-family kinases (SFKs), a group of tyrosine kinases involved in several cellular processes. Its main function has been for long confined to the plasma membrane/cytoplasm compartment, being a myristoylated protein anchored to the cell membrane and functioning downstream to receptors, most of them lacking intrinsic kinase activity. In the last decades, new roles for some SFKs have been described in the nuclear compartment, suggesting that these proteins can also be involved in directly regulating gene transcription or nucleoskeleton architecture. In this review, we focused on those nuclear functions specifically attributable to Src, by considering its function as both tyrosine kinase and adapting molecule. In particular, we addressed the Src involvement in physiological as well as in pathological conditions, especially in tumors.
2020
nucleus; oncogenes; src-family kinases; subcellular localization; tyrosine phosphorylation
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Nuclear functions of the tyrosine kinase Src / Bagnato, G.; Leopizzi, M.; Urciuoli, E.; Peruzzi, B.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 21:8(2020), pp. 1-14. [10.3390/ijms21082675]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1414266
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