The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the presence of replication-competent ZIKV in MSCs from an asymptomatic woman who acquired infection during pregnancy.
Rescue of replication-competent zikv hidden in placenta-derived mesenchymal cells long after the resolution of the infection / Bordoni, V.; Lalle, E.; Colavita, F.; Baiocchini, A.; Nardacci, R.; Falasca, L.; Carletti, F.; Cimini, E.; Bordi, L.; Kobinger, G.; D'Ambrosio, V.; Natale, F.; Giancotti, A.; Manganaro, L.; Del Nonno, F.; Zumla, A.; Liuzzi, G.; Ippolito, G.; Capobianchi, M. R.; Agrati, C.; Castilletti, C.. - In: OPEN FORUM INFECTIOUS DISEASES. - ISSN 2328-8957. - 6:10(2019), pp. 1-4. [10.1093/ofid/ofz342]
Rescue of replication-competent zikv hidden in placenta-derived mesenchymal cells long after the resolution of the infection
Bordoni V.;D'Ambrosio V.;Natale F.;Giancotti A.;Manganaro L.;Capobianchi M. R.;
2019
Abstract
The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the presence of replication-competent ZIKV in MSCs from an asymptomatic woman who acquired infection during pregnancy.| File | Dimensione | Formato | |
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Bordoni_Rescue-replication-competent_2019.pdf
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