Oxidative stress is believed to play a crucial role in the initiation and progression of atherosclerosis. In particular, oxidative stress could be involved in the pathogenesis of hypertension but, until now, there is still a debate whether oxidative stress is a cause or a result of hypertension. Nicotinamide adenine dinucleotide phosphate (NADPH) activation is considered as the major reactive oxygen species source and could be implicated in the pathogenesis of hypertension. A large body of evidences coming from animal studies have generally supported the hypothesis that high blood pressure is associated with increased oxidative stress and with NADPH activation; conversely, human studies provided divergent results. This review analyses the data reported so far to determine the role of NADPH oxidase in the pathogenesis of hypertension. © 2009 Adis Data Information BV. All rights reserved.

The role of nicotinamide adenine dinucleotide phosphate oxidase in the pathogenesis of hypertension / Loffredo, Lorenzo; Violi, Francesco. - In: HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION. - ISSN 1120-9879. - 16:3(2009), pp. 87-92. [10.2165/11316970-000000000-00000]

The role of nicotinamide adenine dinucleotide phosphate oxidase in the pathogenesis of hypertension

LOFFREDO, Lorenzo;VIOLI, Francesco
2009

Abstract

Oxidative stress is believed to play a crucial role in the initiation and progression of atherosclerosis. In particular, oxidative stress could be involved in the pathogenesis of hypertension but, until now, there is still a debate whether oxidative stress is a cause or a result of hypertension. Nicotinamide adenine dinucleotide phosphate (NADPH) activation is considered as the major reactive oxygen species source and could be implicated in the pathogenesis of hypertension. A large body of evidences coming from animal studies have generally supported the hypothesis that high blood pressure is associated with increased oxidative stress and with NADPH activation; conversely, human studies provided divergent results. This review analyses the data reported so far to determine the role of NADPH oxidase in the pathogenesis of hypertension. © 2009 Adis Data Information BV. All rights reserved.
2009
antioxidants; hypertension; nadph oxidase; oxidative stress
01 Pubblicazione su rivista::01a Articolo in rivista
The role of nicotinamide adenine dinucleotide phosphate oxidase in the pathogenesis of hypertension / Loffredo, Lorenzo; Violi, Francesco. - In: HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION. - ISSN 1120-9879. - 16:3(2009), pp. 87-92. [10.2165/11316970-000000000-00000]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/141144
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