Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research. © 2017 The Authors

Molecular definitions of autophagy and related processes / Galluzzi, L.; Baehrecke, E. H.; Ballabio, A.; Boya, P.; Bravo-San Pedro, J. M.; Cecconi, F.; Choi, A. M.; Chu, C. T.; Codogno, P.; Colombo, M. I.; Cuervo, A. M.; Debnath, J.; Deretic, V.; Dikic, I.; Eskelinen, E. -L.; Fimia, G. M.; Fulda, S.; Gewirtz, D. A.; Green, D. R.; Hansen, M.; Harper, J. W.; Jäättelä, M.; Johansen, T.; Juhasz, G.; Kimmelman, A. C.; Kraft, C.; Ktistakis, N. T.; Kumar, S.; Levine, B.; Lopez-Otin, C.; Madeo, F.; Martens, S.; Martinez, J.; Melendez, A.; Mizushima, N.; Münz, C.; Murphy, L. O.; Penninger, J. M.; Piacentini, M.; Reggiori, F.; Rubinsztein, D. C.; Ryan, K. M.; Santambrogio, L.; Scorrano, L.; Simon, A. K.; Simon, H. -U.; Simonsen, A.; Tavernarakis, N.; Tooze, S. A.; Yoshimori, T.; Yuan, J.; Yue, Z.; Zhong, Q.; Kroemer, G.. - In: EMBO JOURNAL. - ISSN 0261-4189. - 36:13(2017), pp. 1811-1836. [10.15252/embj.201796697]

Molecular definitions of autophagy and related processes

Fimia, G. M.;
2017

Abstract

Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research. © 2017 The Authors
2017
aggrephagy; amphisome; autolysosome; autophagosome; autophagy; cell aging, cell degeneration and cell survival; cell death; cell vacuole; chaperone-mediated autophagy; crinophagy; cytoplasm; human; lc3 associated phagocytosis; lipophagocytosis; lysophagy; lysosome; macroautophagy; membrane; microautophagy; mitophagy; nonhuman; nucleophagocytosis; pexophagy; phagocytosis; phagophore; priority journal; proteaphagy; reticulophagy; Review; ribophagy; xenophagy; animal; Caenorhabditis elegans; Drosophila melanogaster; gene regulatory network; mouse; nomenclature; physiology; Saccharomyces cerevisiae, Animals; Autophagy; Caenorhabditis elegans; Drosophila melanogaster; Gene Regulatory Networks; Mice; Saccharomyces cerevisiae; Terminology as Topic; chaperone-mediated autophagy; LC3-associated phagocytosis; microautophagy; mitophagy; xenophagy
01 Pubblicazione su rivista::01a Articolo in rivista
Molecular definitions of autophagy and related processes / Galluzzi, L.; Baehrecke, E. H.; Ballabio, A.; Boya, P.; Bravo-San Pedro, J. M.; Cecconi, F.; Choi, A. M.; Chu, C. T.; Codogno, P.; Colombo, M. I.; Cuervo, A. M.; Debnath, J.; Deretic, V.; Dikic, I.; Eskelinen, E. -L.; Fimia, G. M.; Fulda, S.; Gewirtz, D. A.; Green, D. R.; Hansen, M.; Harper, J. W.; Jäättelä, M.; Johansen, T.; Juhasz, G.; Kimmelman, A. C.; Kraft, C.; Ktistakis, N. T.; Kumar, S.; Levine, B.; Lopez-Otin, C.; Madeo, F.; Martens, S.; Martinez, J.; Melendez, A.; Mizushima, N.; Münz, C.; Murphy, L. O.; Penninger, J. M.; Piacentini, M.; Reggiori, F.; Rubinsztein, D. C.; Ryan, K. M.; Santambrogio, L.; Scorrano, L.; Simon, A. K.; Simon, H. -U.; Simonsen, A.; Tavernarakis, N.; Tooze, S. A.; Yoshimori, T.; Yuan, J.; Yue, Z.; Zhong, Q.; Kroemer, G.. - In: EMBO JOURNAL. - ISSN 0261-4189. - 36:13(2017), pp. 1811-1836. [10.15252/embj.201796697]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1411051
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