Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research. © 2017 The Authors
Molecular definitions of autophagy and related processes / Galluzzi, L.; Baehrecke, E. H.; Ballabio, A.; Boya, P.; Bravo-San Pedro, J. M.; Cecconi, F.; Choi, A. M.; Chu, C. T.; Codogno, P.; Colombo, M. I.; Cuervo, A. M.; Debnath, J.; Deretic, V.; Dikic, I.; Eskelinen, E. -L.; Fimia, G. M.; Fulda, S.; Gewirtz, D. A.; Green, D. R.; Hansen, M.; Harper, J. W.; Jäättelä, M.; Johansen, T.; Juhasz, G.; Kimmelman, A. C.; Kraft, C.; Ktistakis, N. T.; Kumar, S.; Levine, B.; Lopez-Otin, C.; Madeo, F.; Martens, S.; Martinez, J.; Melendez, A.; Mizushima, N.; Münz, C.; Murphy, L. O.; Penninger, J. M.; Piacentini, M.; Reggiori, F.; Rubinsztein, D. C.; Ryan, K. M.; Santambrogio, L.; Scorrano, L.; Simon, A. K.; Simon, H. -U.; Simonsen, A.; Tavernarakis, N.; Tooze, S. A.; Yoshimori, T.; Yuan, J.; Yue, Z.; Zhong, Q.; Kroemer, G.. - In: EMBO JOURNAL. - ISSN 0261-4189. - 36:13(2017), pp. 1811-1836. [10.15252/embj.201796697]
Molecular definitions of autophagy and related processes
Fimia, G. M.;
2017
Abstract
Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research. © 2017 The Authors| File | Dimensione | Formato | |
|---|---|---|---|
|
Molecular Definitions of Autophagy and Related Processes.pdf
accesso aperto
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
971.16 kB
Formato
Adobe PDF
|
971.16 kB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
