The identification of somatic mutations in cancer specimens enables detection of molecular markers for personalized treatment. We recently developed a novel molecular assay and evaluated its clinical performance as an ancillary molecular method for indeterminate thyroid nodule cytology. Herein we describe the analytical validation of the novel targeted next-generation sequencing (NGS) assay in thyroid samples from different sources.

Analytical validation of a novel targeted next-generation sequencing assay for mutation detection in thyroid nodule aspirates and tissue / Verrienti, Antonella; Pecce, Valeria; Abballe, Luana; Ramundo, Valeria; Falcone, Rosa; Inanloo Nigi Jak, Farzaneh; Brunelli, Chiara; Fadda, Guido; Bosco, Daniela; Ascoli, Valeria; Carletti, Raffaella; Di Gioia, Cira; Grani, Giorgio; Sponziello, Marialuisa. - In: ENDOCRINE. - ISSN 1355-008X. - 69:2(2020), pp. 451-455. [10.1007/s12020-020-02372-8]

Analytical validation of a novel targeted next-generation sequencing assay for mutation detection in thyroid nodule aspirates and tissue

Verrienti, Antonella
Co-primo
;
Pecce, Valeria
Co-primo
;
Abballe, Luana
;
Ramundo, Valeria;Falcone, Rosa;Inanloo Nigi Jak, Farzaneh;Bosco, Daniela;Ascoli, Valeria;Carletti, Raffaella;Di Gioia, Cira;Grani, Giorgio
Penultimo
;
Sponziello, Marialuisa
Ultimo
2020

Abstract

The identification of somatic mutations in cancer specimens enables detection of molecular markers for personalized treatment. We recently developed a novel molecular assay and evaluated its clinical performance as an ancillary molecular method for indeterminate thyroid nodule cytology. Herein we describe the analytical validation of the novel targeted next-generation sequencing (NGS) assay in thyroid samples from different sources.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1409724
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