Globins have been found in glial cells and neurons of invertebrates and vertebrates. The first nerve globin has been recognized in the nerve cord of the polychaete annelid Aphrodite aculeata in 1872. In some invertebrates, the nerve globin reaches a millimolar concentration which is likely sufficient to sustain the aerobic metabolism and thus the excitability of the nervous system. In 2000, the first vertebrate nerve globin, named neuroglobin (Ngb), has been identified in neuronal tissues of mice and humans. In contrast to invertebrate nerve globins, the concentration of Ngb, the prototype of vertebrate nerve globins, is low (μM), reaching a maximum of 100 μM in retina cells. Therefore, Ngb appears unlikely to act primarily as an O₂ buffer and to facilitate O₂ diffusion to the mitochondria. Indeed, Ngb has been hypothesized to catalyze the formation/decomposition of reactive nitrogen and/or oxygen species and to be part of intracellular signaling pathways enhancing cell survival. Here, we report that neuronal Ngb levels are strongly induced by the steroid hormone 17β-estradiol. Furthermore, Ngb participates to mechanisms involved in 17β-estradiol-induced protective effects against H₂O₂ -induced neurotoxicity.

Neuroglobin, estrogens, and neuroprotection / De Marinis, Elisabetta; Marino, Maria; Ascenzi, Paolo. - In: IUBMB LIFE. - ISSN 1521-6551. - 63:3(2011), p. 140-5. [10.1002/iub.426]

Neuroglobin, estrogens, and neuroprotection

De Marinis, Elisabetta
Primo
;
2011

Abstract

Globins have been found in glial cells and neurons of invertebrates and vertebrates. The first nerve globin has been recognized in the nerve cord of the polychaete annelid Aphrodite aculeata in 1872. In some invertebrates, the nerve globin reaches a millimolar concentration which is likely sufficient to sustain the aerobic metabolism and thus the excitability of the nervous system. In 2000, the first vertebrate nerve globin, named neuroglobin (Ngb), has been identified in neuronal tissues of mice and humans. In contrast to invertebrate nerve globins, the concentration of Ngb, the prototype of vertebrate nerve globins, is low (μM), reaching a maximum of 100 μM in retina cells. Therefore, Ngb appears unlikely to act primarily as an O₂ buffer and to facilitate O₂ diffusion to the mitochondria. Indeed, Ngb has been hypothesized to catalyze the formation/decomposition of reactive nitrogen and/or oxygen species and to be part of intracellular signaling pathways enhancing cell survival. Here, we report that neuronal Ngb levels are strongly induced by the steroid hormone 17β-estradiol. Furthermore, Ngb participates to mechanisms involved in 17β-estradiol-induced protective effects against H₂O₂ -induced neurotoxicity.
2011
Animals; Apoptosis; Estrogens; Globins; Humans; Mice; Nerve Tissue Proteins; Neuroglobin; Up-Regulation; Neuroprotective Agents
01 Pubblicazione su rivista::01a Articolo in rivista
Neuroglobin, estrogens, and neuroprotection / De Marinis, Elisabetta; Marino, Maria; Ascenzi, Paolo. - In: IUBMB LIFE. - ISSN 1521-6551. - 63:3(2011), p. 140-5. [10.1002/iub.426]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1409456
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