A novel injectable hydrogel with sustained drug release properties was formulated using DNA as the base polymer matrix and two-dimensional silicate nanodisks (nSi) as an active center for the gelation process. The base pair recognition properties of DNA strands as well as the electrostatic interactions of DNA with nSi facilitated the formation of a physically crosslinked hydrogel network, without the requirement of cytotoxic chemical crosslinkers or prior functionalization steps. The non-covalent nature of the crosslinking method enables a rapid recovery of storage moduli after the injection process, thereby reducing the risk of getting washed away from the defect region. Additionally, the silicate nanodisks were able to modulate the drug release properties of the designed network due to their high surface area and anisotropic charge distribution. Methods: DNA solutions (4% w/v) were heated at 90°C.
Nanoengineered dna based injectable hydrogels as sustained drug delivery platform for cranial defect repair / Basu, S.; Pacelli, S.; Feng, Y.; Lu, Q.; Wang, J.; Paul, A.. - 40:(2019), p. 42. (Intervento presentato al convegno 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence tenutosi a Seattle, United States).
Nanoengineered dna based injectable hydrogels as sustained drug delivery platform for cranial defect repair
Pacelli S.;
2019
Abstract
A novel injectable hydrogel with sustained drug release properties was formulated using DNA as the base polymer matrix and two-dimensional silicate nanodisks (nSi) as an active center for the gelation process. The base pair recognition properties of DNA strands as well as the electrostatic interactions of DNA with nSi facilitated the formation of a physically crosslinked hydrogel network, without the requirement of cytotoxic chemical crosslinkers or prior functionalization steps. The non-covalent nature of the crosslinking method enables a rapid recovery of storage moduli after the injection process, thereby reducing the risk of getting washed away from the defect region. Additionally, the silicate nanodisks were able to modulate the drug release properties of the designed network due to their high surface area and anisotropic charge distribution. Methods: DNA solutions (4% w/v) were heated at 90°C.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
