Statement of Purpose: Stem cell-based therapies represent a valid approach to restore cardiac function due to their beneficial effect in reducing scar area formation and promoting angiogenesis. However, their translation into the clinic is limited by the poor differentiation and inability to secrete sufficient therapeutic factors. To address this issue, several strategies such as genetic modification and biophysical pre-conditioning have been used to enhance the efficacy of stem cells for cardiac tissue repair.
Mechanobiologically-activated, scaffold-free transplantation of stem cells to repair injured cardiac tissues / Paul, A.; Chakravarti, A. R.; Pacelli, S.; Alam, P.; Modaresi, S.; Ahmed, R. P. H.. - 40:(2019), p. 255. (Intervento presentato al convegno 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence tenutosi a Seattle, United States).
Mechanobiologically-activated, scaffold-free transplantation of stem cells to repair injured cardiac tissues
Pacelli S.;
2019
Abstract
Statement of Purpose: Stem cell-based therapies represent a valid approach to restore cardiac function due to their beneficial effect in reducing scar area formation and promoting angiogenesis. However, their translation into the clinic is limited by the poor differentiation and inability to secrete sufficient therapeutic factors. To address this issue, several strategies such as genetic modification and biophysical pre-conditioning have been used to enhance the efficacy of stem cells for cardiac tissue repair.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
