Statement of Purpose: Myocardial infarction (MI) is amongst the main causes of mortality worldwide, affecting people across a wide range of ages. Stem cell-based therapies are a viable approach to repair cardiovascular tissues due to their advantageous effect in promoting angiogenesis and decreasing scar tissue development. But, their translation to the clinic is hindered by their lack of ability to secrete sufficient therapeutic factors and poor differentiation in vivo. To combat this problem, various strategies like genetic modification and biophysical pre-conditioning have aimed at enhancing the efficacy of stem cells for cardiovascular tissue regeneration.
Engineering a biomimetic environment to pre-condition stem cells for efficacious cardiovascular repair / Chakravarti, Aparna R.; Pacelli, Settimio; Alam, Perwez; Bagchi, Samik; Modaresi, Saman; Czirók, A.; Ahmed, Rafeeq P. H.; Paul, Arghya. - (2019). (Intervento presentato al convegno 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence tenutosi a Seattle, United States).
Engineering a biomimetic environment to pre-condition stem cells for efficacious cardiovascular repair
Settimio Pacelli;
2019
Abstract
Statement of Purpose: Myocardial infarction (MI) is amongst the main causes of mortality worldwide, affecting people across a wide range of ages. Stem cell-based therapies are a viable approach to repair cardiovascular tissues due to their advantageous effect in promoting angiogenesis and decreasing scar tissue development. But, their translation to the clinic is hindered by their lack of ability to secrete sufficient therapeutic factors and poor differentiation in vivo. To combat this problem, various strategies like genetic modification and biophysical pre-conditioning have aimed at enhancing the efficacy of stem cells for cardiovascular tissue regeneration.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
