The aim of the study is to observe retrospectively the correlation between Oral Squamous Cell Carcinoma (OSCC) and risk factors; including tobacco, alcohol and Family History of Cancer (FHC). A total of 478 patients were included retrospectively from the database of the Department of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome. A Test Group (TG) consisted of 239 patients with a confirmed diagnosis of OSCC. A Control Group (CG) consisted of 239 patients without history and/or diagnosis of oral cancer. The logistic regression models were used to calculate the adjusted Odd Ratios (ORs) associated with alcohol, tobacco and FHC; including the General Family History of Cancer (GFHC) and Family History of Head and Neck Cancer (FHHNC) and their 95% Confidence Intervals (CI). The high rate of tobacco consumption was associated with an OR of 1.035 (95% CI 1.001–1.070) and a statistical significance (p = 0.041). Drinker patients showed a significant risk of developing OSCC (p = 0.05) and the OR was 1.035 (95% CI 1.010–1.061). The GFHC was associated with a marginal risk of OSCC with an OR of 1.095 (95% CI 0.953–1.259), without significance (p = 0.199). The FHHNC showed a notable risk increase with an OR of 1.871 (95% CI 0.902–3.882), without significance (p = 0.092). Alcohol and tobacco may be associated with an increase in the risk of OSCC.

Tobacco, alcohol and family history of cancer as risk factors of oral squamous cell carcinoma: case-control retrospective study / Tenore, Gianluca; Nuvoli, Alessandro; Mohsen, AHMED AMIR MOHAMED; Cassoni, Andrea; Battisti, Andrea; Terenzi, Valentina; Della Monaca, Marco; Raponi, Ingrid; Brauner, Edoardo; DE FELICE, Francesca; Musio, Daniela; DI GIOIA, Cira Rosaria Tiziana; Messineo, Daniela; Mezi, Silvia; DI CARLO, Stefano; Botticelli, Andrea; Valentini, Valentino; Marchetti, Paolo; Tombolini, Vincenzo; DE VINCENTIIS, Marco; Polimeni, Antonella; Romeo, Umberto. - In: APPLIED SCIENCES. - ISSN 2076-3417. - 10:11(2020), pp. 1-11. [10.3390/app10113896]

Tobacco, alcohol and family history of cancer as risk factors of oral squamous cell carcinoma: case-control retrospective study

Gianluca Tenore
Primo
;
Ahmed Mohsen
;
Andrea Cassoni;Andrea Battisti;Valentina Terenzi;Marco Della Monaca;Ingrid Raponi;Edoardo Brauner;Francesca De Felice;Cira Rosaria Tiziana Di Gioia;Daniela Messineo;Silvia Mezi;Stefano Di Carlo;Andrea Botticelli;Valentino Valentini;Paolo Marchetti;Vincenzo Tombolini;Marco De Vincentiis;Antonella Polimeni
Penultimo
;
Umberto Romeo.
Ultimo
2020

Abstract

The aim of the study is to observe retrospectively the correlation between Oral Squamous Cell Carcinoma (OSCC) and risk factors; including tobacco, alcohol and Family History of Cancer (FHC). A total of 478 patients were included retrospectively from the database of the Department of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome. A Test Group (TG) consisted of 239 patients with a confirmed diagnosis of OSCC. A Control Group (CG) consisted of 239 patients without history and/or diagnosis of oral cancer. The logistic regression models were used to calculate the adjusted Odd Ratios (ORs) associated with alcohol, tobacco and FHC; including the General Family History of Cancer (GFHC) and Family History of Head and Neck Cancer (FHHNC) and their 95% Confidence Intervals (CI). The high rate of tobacco consumption was associated with an OR of 1.035 (95% CI 1.001–1.070) and a statistical significance (p = 0.041). Drinker patients showed a significant risk of developing OSCC (p = 0.05) and the OR was 1.035 (95% CI 1.010–1.061). The GFHC was associated with a marginal risk of OSCC with an OR of 1.095 (95% CI 0.953–1.259), without significance (p = 0.199). The FHHNC showed a notable risk increase with an OR of 1.871 (95% CI 0.902–3.882), without significance (p = 0.092). Alcohol and tobacco may be associated with an increase in the risk of OSCC.
2020
alcohol; family history of cancer; head and neck cancer; oral cancer; oral squamous cell carcinoma; smoking; tobacco
01 Pubblicazione su rivista::01a Articolo in rivista
Tobacco, alcohol and family history of cancer as risk factors of oral squamous cell carcinoma: case-control retrospective study / Tenore, Gianluca; Nuvoli, Alessandro; Mohsen, AHMED AMIR MOHAMED; Cassoni, Andrea; Battisti, Andrea; Terenzi, Valentina; Della Monaca, Marco; Raponi, Ingrid; Brauner, Edoardo; DE FELICE, Francesca; Musio, Daniela; DI GIOIA, Cira Rosaria Tiziana; Messineo, Daniela; Mezi, Silvia; DI CARLO, Stefano; Botticelli, Andrea; Valentini, Valentino; Marchetti, Paolo; Tombolini, Vincenzo; DE VINCENTIIS, Marco; Polimeni, Antonella; Romeo, Umberto. - In: APPLIED SCIENCES. - ISSN 2076-3417. - 10:11(2020), pp. 1-11. [10.3390/app10113896]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1408185
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