Biallelic mutations in the ITK gene cause a T-cell primary immunodeficiency with Epstein-Barr virus (EBV)-lymphoproliferative disorders. We describe a novel association of a homozygous ITK mutation with β-human papillomavirus (HPV)-positive epidermodysplasia verruciformis. Thus, loss of function in ITK can result in broad dysregulation of T-cell responses to oncogenic viruses, including β-HPV and EBV.
Inherited interleukin 2-Inducible T-Cell (ITK) kinase deficiency in siblings with epidermodysplasia verruciformis and hodgkin lymphoma / Youssefian, L.; Vahidnezhad, H.; Yousefi, M.; Saeidian, A. H.; Azizpour, A.; Touati, A.; Nikbakht, N.; Hesari, K. K. -.; Adib-Sereshki, M. M.; Zeinali, S.; Mansoori, B.; Jazayeri, A.; Karamzadeh, R.; Fortina, P.; Jouanguy, E.; Casanova, J. -L.; Uitto, J.. - In: CLINICAL INFECTIOUS DISEASES. - ISSN 1058-4838. - 68:11(2019), pp. 1938-1941. [10.1093/cid/ciy942]
Inherited interleukin 2-Inducible T-Cell (ITK) kinase deficiency in siblings with epidermodysplasia verruciformis and hodgkin lymphoma
Yousefi M.;Fortina P.;
2019
Abstract
Biallelic mutations in the ITK gene cause a T-cell primary immunodeficiency with Epstein-Barr virus (EBV)-lymphoproliferative disorders. We describe a novel association of a homozygous ITK mutation with β-human papillomavirus (HPV)-positive epidermodysplasia verruciformis. Thus, loss of function in ITK can result in broad dysregulation of T-cell responses to oncogenic viruses, including β-HPV and EBV.| File | Dimensione | Formato | |
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