Biallelic mutations in the ITK gene cause a T-cell primary immunodeficiency with Epstein-Barr virus (EBV)-lymphoproliferative disorders. We describe a novel association of a homozygous ITK mutation with β-human papillomavirus (HPV)-positive epidermodysplasia verruciformis. Thus, loss of function in ITK can result in broad dysregulation of T-cell responses to oncogenic viruses, including β-HPV and EBV.
Inherited interleukin 2-Inducible T-Cell (ITK) kinase deficiency in siblings with epidermodysplasia verruciformis and hodgkin lymphoma / Youssefian, L., Vahidnezhad, H., Yousefi, M., Saeidian, A.H., Azizpour, A., Touati, A., Nikbakht, N., Hesari, K.K.-., Adib-Sereshki, M.M., Zeinali, S., Mansoori, B., Jazayeri, A., Karamzadeh, R., Fortina, P., Jouanguy, E., Casanova, J.-L., Uitto, J.. - In: CLINICAL INFECTIOUS DISEASES. - ISSN 1058-4838. - 68:11(2019), pp. 1938-1941. [10.1093/cid/ciy942]
Inherited interleukin 2-Inducible T-Cell (ITK) kinase deficiency in siblings with epidermodysplasia verruciformis and hodgkin lymphoma
Yousefi M.;Fortina P.;
2019
Abstract
Biallelic mutations in the ITK gene cause a T-cell primary immunodeficiency with Epstein-Barr virus (EBV)-lymphoproliferative disorders. We describe a novel association of a homozygous ITK mutation with β-human papillomavirus (HPV)-positive epidermodysplasia verruciformis. Thus, loss of function in ITK can result in broad dysregulation of T-cell responses to oncogenic viruses, including β-HPV and EBV.| File | Dimensione | Formato | |
|---|---|---|---|
|
Youssefian_Inherited-interleukin_2019.pdf
accesso aperto
Tipologia:
Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
1.32 MB
Formato
Adobe PDF
|
1.32 MB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
