Introduction: Molecular, functional, and structural neuroimaging biomarkers are largely used to study neurodegenerative diseases, but their benefits to patients/science might be greatly enhanced by improving standardization and cross-validation. In this EU Joint Programme-Neurodegenerative Diseases Research–funded project, we surveyed the neuroimaging community to assess perceived barriers in multicentric neuroimaging harmonization and actions to overcome them. Methods: An anonymous survey addressed researchers, clinicians, pharma industry, and professional associations, inquiring about both general and modality-specific harmonization barriers. Results: Survey participants (459) represented an international (37 countries) multidisciplinary community. We identified two sets of funding actions, one proposing the creation of an updated hub of documents to help researchers plan and execute multicentric neuroimaging studies capitalizing from previous studies, and the other focused on modality-specific harmonization challenges in future neurodegenerative diseases clinical trials. Discussion: This large survey of priorities and actions may help define harmonization calls launched by worldwide science funding agencies.

Harmonization of neuroimaging biomarkers for neurodegenerative diseases: a survey in the imaging community of perceived barriers and suggested actions / Jovicich, J.; Barkhof, F.; Babiloni, C.; Herholz, K.; Mulert, C.; van Berckel, B. N. M.; Frisoni, G. B.. - In: ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING. - ISSN 2352-8729. - 11:1(2019), pp. 69-73. [10.1016/j.dadm.2018.11.005]

Harmonization of neuroimaging biomarkers for neurodegenerative diseases: a survey in the imaging community of perceived barriers and suggested actions

Babiloni C.;
2019

Abstract

Introduction: Molecular, functional, and structural neuroimaging biomarkers are largely used to study neurodegenerative diseases, but their benefits to patients/science might be greatly enhanced by improving standardization and cross-validation. In this EU Joint Programme-Neurodegenerative Diseases Research–funded project, we surveyed the neuroimaging community to assess perceived barriers in multicentric neuroimaging harmonization and actions to overcome them. Methods: An anonymous survey addressed researchers, clinicians, pharma industry, and professional associations, inquiring about both general and modality-specific harmonization barriers. Results: Survey participants (459) represented an international (37 countries) multidisciplinary community. We identified two sets of funding actions, one proposing the creation of an updated hub of documents to help researchers plan and execute multicentric neuroimaging studies capitalizing from previous studies, and the other focused on modality-specific harmonization challenges in future neurodegenerative diseases clinical trials. Discussion: This large survey of priorities and actions may help define harmonization calls launched by worldwide science funding agencies.
2019
Biomarker; EEG; Electroencephalography; Harmonization; Magnetic resonance imaging; MRI; Multicentric; Multisite; Neurodegeneration; Neuroimaging; PET; Photon emission computed tomography; Positron emission tomography; SPECT; Survey
01 Pubblicazione su rivista::01a Articolo in rivista
Harmonization of neuroimaging biomarkers for neurodegenerative diseases: a survey in the imaging community of perceived barriers and suggested actions / Jovicich, J.; Barkhof, F.; Babiloni, C.; Herholz, K.; Mulert, C.; van Berckel, B. N. M.; Frisoni, G. B.. - In: ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING. - ISSN 2352-8729. - 11:1(2019), pp. 69-73. [10.1016/j.dadm.2018.11.005]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1407466
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