Despite the current pandemic season, reports on pathologic features of coronavirus disease 19 (Covid-19) are exceedingly rare at the present time. Here we describe the pathologic features of early lung involvement by Covid-19 in a surgical sample resected for carcinoma from a patient who developed SARS-CoV-2 infection soon after surgery. The main histologic findings observed were pneumocyte damage, alveolar hemorrhages with clustering of macrophages, prominent and diffuse neutrophilic margination within septal vessels, and interstitial inflammatory infiltrates, mainly represented by CD8+ T lymphocytes. These features are similar to those previously described in SARS-CoV-2 infection. Subtle histologic changes suggestive pulmonary involvement by Covid-19 may be accidentally encountered in routine pathology practice, especially when extensive sampling is performed for histology. These findings should be carefully interpreted in light of the clinical context of the patient and could prompt a pharyngeal swab PCR test to rule out the possibility of SARS-CoV-2 infection in asymptomatic patients.

Early histologic findings of pulmonary SARS-CoV-2 infection detected in a surgical specimen / Pernazza, A.; Mancini, M.; Rullo, E.; Bassi, M.; De Giacomo, T.; della rocca, C; D'Amati, G.. - In: VIRCHOWS ARCHIV. - ISSN 0945-6317. - (2020). [10.1007/s00428-020-02829-1]

Early histologic findings of pulmonary SARS-CoV-2 infection detected in a surgical specimen

Pernazza A.;Mancini M.;Rullo E.;Bassi M.;De Giacomo T.;della rocca C;d'Amati G.
2020

Abstract

Despite the current pandemic season, reports on pathologic features of coronavirus disease 19 (Covid-19) are exceedingly rare at the present time. Here we describe the pathologic features of early lung involvement by Covid-19 in a surgical sample resected for carcinoma from a patient who developed SARS-CoV-2 infection soon after surgery. The main histologic findings observed were pneumocyte damage, alveolar hemorrhages with clustering of macrophages, prominent and diffuse neutrophilic margination within septal vessels, and interstitial inflammatory infiltrates, mainly represented by CD8+ T lymphocytes. These features are similar to those previously described in SARS-CoV-2 infection. Subtle histologic changes suggestive pulmonary involvement by Covid-19 may be accidentally encountered in routine pathology practice, especially when extensive sampling is performed for histology. These findings should be carefully interpreted in light of the clinical context of the patient and could prompt a pharyngeal swab PCR test to rule out the possibility of SARS-CoV-2 infection in asymptomatic patients.
2020
Covid-19; Lung histology; Pathology; SARS-CoV-2
01 Pubblicazione su rivista::01a Articolo in rivista
Early histologic findings of pulmonary SARS-CoV-2 infection detected in a surgical specimen / Pernazza, A.; Mancini, M.; Rullo, E.; Bassi, M.; De Giacomo, T.; della rocca, C; D'Amati, G.. - In: VIRCHOWS ARCHIV. - ISSN 0945-6317. - (2020). [10.1007/s00428-020-02829-1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1407289
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