The involvement of epigenetics mechanisms in the transcriptional regulation of key genes has been investigated in the initiation and progression of neurodegenerative disorders, including Parkinson's disease (PD). Among others, we, here, focused the attention on the dopamine transporter (DAT) gene playing a critical role in maintaining the integrity of dopaminergic neurons.
DNA methylation of the 5'-UTR DAT 1 gene in Parkinson's disease patients / Rubino, Alfonso; D'Addario, Claudio; Di Bartolomeo, Martina; Michele Salamone, Enrico; Locuratolo, Nicoletta; Fattapposta, Francesco; Vanacore, Nicola; Pascale, Esterina. - In: ACTA NEUROLOGICA SCANDINAVICA. - ISSN 0001-6314. - (2020). [10.1111/ane.13279]
DNA methylation of the 5'-UTR DAT 1 gene in Parkinson's disease patients
Rubino, Alfonso;Michele Salamone, Enrico;Locuratolo, Nicoletta;Fattapposta, Francesco;Vanacore, Nicola;Pascale, Esterina
2020
Abstract
The involvement of epigenetics mechanisms in the transcriptional regulation of key genes has been investigated in the initiation and progression of neurodegenerative disorders, including Parkinson's disease (PD). Among others, we, here, focused the attention on the dopamine transporter (DAT) gene playing a critical role in maintaining the integrity of dopaminergic neurons.| File | Dimensione | Formato | |
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