(1) Background: In dystonia, the somatosensory temporal discrimination threshold (STDT) is abnormally increased at rest and higher and longer-lasting during movement execution in comparison with healthy subjects (HS), suggesting an abnormal sensorimotor integration. These abnormalities are thought to depend on abnormal proprioceptive input coming from dystonic muscles. Since Botulinum toxin-A (BT-A) reduces proprioceptive input in the injected muscles, our study investigated the effects of BT-A on STDT tested at rest and during voluntary movement execution in patients with focal dystonia. (2) Methods: We enrolled 35 patients with focal dystonia: 14 patients with cervical dystonia (CD), 11 patients with blepharospasm (BSP), and 10 patients with focal hand dystonia (FHD); and 12 age-matched HS. STDT tested by delivering paired stimuli was measured in all subjects at rest and during index finger abductions. (3) Results: Patients with dystonia had higher STDT values at rest and during movement execution than HS. While BT-A did not modify STDT at rest, it reduced the abnormal values of STDT during movement in CD and FHD patients, but not in BSP patients. (4) Conclusions: BT-A improved abnormal sensorimotor integration in CD and FHD, most likely by decreasing the overflow of proprioceptive signaling from muscle dystonic activity to the thalamus.

Botulinum toxin effects on sensorimotor integration in focal dystonias / De Bartolo, M. I.; Manzo, N.; Ferrazzano, G.; Baione, V.; Belvisi, D.; Fabbrini, G.; Berardelli, A.; Conte, A.. - In: TOXINS. - ISSN 2072-6651. - 12:5(2020), p. 277. [10.3390/toxins12050277]

Botulinum toxin effects on sensorimotor integration in focal dystonias

De Bartolo M. I.;Manzo N.;Ferrazzano G.;Baione V.;Belvisi D.;Fabbrini G.;Berardelli A.;Conte A.
2020

Abstract

(1) Background: In dystonia, the somatosensory temporal discrimination threshold (STDT) is abnormally increased at rest and higher and longer-lasting during movement execution in comparison with healthy subjects (HS), suggesting an abnormal sensorimotor integration. These abnormalities are thought to depend on abnormal proprioceptive input coming from dystonic muscles. Since Botulinum toxin-A (BT-A) reduces proprioceptive input in the injected muscles, our study investigated the effects of BT-A on STDT tested at rest and during voluntary movement execution in patients with focal dystonia. (2) Methods: We enrolled 35 patients with focal dystonia: 14 patients with cervical dystonia (CD), 11 patients with blepharospasm (BSP), and 10 patients with focal hand dystonia (FHD); and 12 age-matched HS. STDT tested by delivering paired stimuli was measured in all subjects at rest and during index finger abductions. (3) Results: Patients with dystonia had higher STDT values at rest and during movement execution than HS. While BT-A did not modify STDT at rest, it reduced the abnormal values of STDT during movement in CD and FHD patients, but not in BSP patients. (4) Conclusions: BT-A improved abnormal sensorimotor integration in CD and FHD, most likely by decreasing the overflow of proprioceptive signaling from muscle dystonic activity to the thalamus.
2020
Blepharospasm; Botulinum toxin A; Cervical dystonia; Focal dystonia; Focal hand dystonia; Sensorimotor integration; Somatosensory temporal discrimination threshold
01 Pubblicazione su rivista::01a Articolo in rivista
Botulinum toxin effects on sensorimotor integration in focal dystonias / De Bartolo, M. I.; Manzo, N.; Ferrazzano, G.; Baione, V.; Belvisi, D.; Fabbrini, G.; Berardelli, A.; Conte, A.. - In: TOXINS. - ISSN 2072-6651. - 12:5(2020), p. 277. [10.3390/toxins12050277]
File allegati a questo prodotto
File Dimensione Formato  
De Bartolo_Botulinum Toxin Effects_2020.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 720.36 kB
Formato Adobe PDF
720.36 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1405597
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 6
social impact