Cytotoxic T lymphocytes constantly monitor peptide-MHC class I complexes on the cell surface to eliminate transformed and virally infected cells expressing peptides derived from abnormal proteins. The generation of antigenic peptides and their loading on MHC class I molecules is a multistep process involving different molecules that constitute the so-called antigen processing and presentation machinery (APM). To avoid immune-mediated elimination, human tumors and pathogens have adopted different strategies including loss of MHC class I expression and dysregulation of APM genes and proteins. Here, we summarize recent knowledge on genetic variations in APM genes and their association with cancer development and viral-mediated diseases.
Role of genetic variations on MHC class I antigen-processing genes in human cancer and viral-mediated diseases / D'Alicandro, V.; Romania, P.; Melaiu, O.; Fruci, D.. - In: MOLECULAR IMMUNOLOGY. - ISSN 0161-5890. - 113:(2019), pp. 11-15. [10.1016/j.molimm.2018.03.024]
Role of genetic variations on MHC class I antigen-processing genes in human cancer and viral-mediated diseases
D'Alicandro, V.;Romania, P.;
2019
Abstract
Cytotoxic T lymphocytes constantly monitor peptide-MHC class I complexes on the cell surface to eliminate transformed and virally infected cells expressing peptides derived from abnormal proteins. The generation of antigenic peptides and their loading on MHC class I molecules is a multistep process involving different molecules that constitute the so-called antigen processing and presentation machinery (APM). To avoid immune-mediated elimination, human tumors and pathogens have adopted different strategies including loss of MHC class I expression and dysregulation of APM genes and proteins. Here, we summarize recent knowledge on genetic variations in APM genes and their association with cancer development and viral-mediated diseases.File | Dimensione | Formato | |
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