BACKGROUND: In this neurophysiological study, we aimed at verifying the nociceptive selectivity of the new, micropatterned electrode (150IDE), recently designed to generate an electric field limited to the intraepidermal free nerve endings. METHODS: Using the new 150IDE, we recorded evoked potentials after stimulation of the face and hand dorsum in 22 healthy participants and in patients with exemplary conditions selectively affecting the nociceptive system. We also measured the peripheral conduction velocity at the upper arm and verified the nociceptive selectivity of 150IDE assessing the effect of a selective block of nociceptive nerve fibres of radial nerve with local anaesthetic infiltration. In healthy participants and in patients, we have also compared the 150IDE-evoked potentials with laser-evoked potentials. RESULTS: In healthy participants, the 150IDE-evoked pinprick sensation and reproducible scalp potentials, with latency similar to laser-evoked potentials. The mean peripheral conduction velocity, estimated at the upper arm, was 12 m/s. The selective nociceptive fibre block of the radial nerve abolished the scalp potentials elicited by the 150IDE stimulation. In patients, the

The new micropatterned interdigitated electrode for selective assessment of the nociceptive system / Di Stefano, Giulia; Di Lionardo, Andrea; La Cesa, Silvia; Di Pietro, Giuseppe; Fasolino, Alessandra; Galosi, Eleonora; Leone, Caterina; Cruccu, Giorgio; Marinelli, Lucio; Leandri, Massimo; Truini, Andrea. - In: EUROPEAN JOURNAL OF PAIN. - ISSN 1090-3801. - 24:5(2020), pp. 956-966. [10.1002/ejp.1545]

The new micropatterned interdigitated electrode for selective assessment of the nociceptive system

Di Stefano, Giulia;Di Lionardo, Andrea;La Cesa, Silvia;Di Pietro, Giuseppe;Fasolino, Alessandra;Galosi, Eleonora;Leone, Caterina;Cruccu, Giorgio;Truini, Andrea
2020

Abstract

BACKGROUND: In this neurophysiological study, we aimed at verifying the nociceptive selectivity of the new, micropatterned electrode (150IDE), recently designed to generate an electric field limited to the intraepidermal free nerve endings. METHODS: Using the new 150IDE, we recorded evoked potentials after stimulation of the face and hand dorsum in 22 healthy participants and in patients with exemplary conditions selectively affecting the nociceptive system. We also measured the peripheral conduction velocity at the upper arm and verified the nociceptive selectivity of 150IDE assessing the effect of a selective block of nociceptive nerve fibres of radial nerve with local anaesthetic infiltration. In healthy participants and in patients, we have also compared the 150IDE-evoked potentials with laser-evoked potentials. RESULTS: In healthy participants, the 150IDE-evoked pinprick sensation and reproducible scalp potentials, with latency similar to laser-evoked potentials. The mean peripheral conduction velocity, estimated at the upper arm, was 12 m/s. The selective nociceptive fibre block of the radial nerve abolished the scalp potentials elicited by the 150IDE stimulation. In patients, the
2020
neuropathic pain, laser evoked potentials, small-fibre neuropathy
01 Pubblicazione su rivista::01a Articolo in rivista
The new micropatterned interdigitated electrode for selective assessment of the nociceptive system / Di Stefano, Giulia; Di Lionardo, Andrea; La Cesa, Silvia; Di Pietro, Giuseppe; Fasolino, Alessandra; Galosi, Eleonora; Leone, Caterina; Cruccu, Giorgio; Marinelli, Lucio; Leandri, Massimo; Truini, Andrea. - In: EUROPEAN JOURNAL OF PAIN. - ISSN 1090-3801. - 24:5(2020), pp. 956-966. [10.1002/ejp.1545]
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