It is becoming increasingly clear that astrocytes play an active role in neural communications by releasing neuro-active gliotransmitters into extra-cellular spaces, where they act on neighbouring neurons in order to modulate synaptic transmission and plasticity, and affect behaviour. However, in terms of cell biology, our knowledge of the mechanisms governing the secretion of gliotransmitters is so much less detailed than our knowledge of those governing neurotransmitters that it has even been questioned whether astrocytes are capable of secreting molecules. This review critically evaluates the currently available findings concerning gliotransmitters with the aim of stimulating discussion in the field.

Novel insights into gliotransmitters / Petrelli, F.; Bezzi, P.. - In: CURRENT OPINION IN PHARMACOLOGY. - ISSN 1471-4892. - 26:(2016), pp. 138-145. [10.1016/j.coph.2015.11.010]

Novel insights into gliotransmitters

Bezzi P.
Ultimo
Writing – Original Draft Preparation
2016

Abstract

It is becoming increasingly clear that astrocytes play an active role in neural communications by releasing neuro-active gliotransmitters into extra-cellular spaces, where they act on neighbouring neurons in order to modulate synaptic transmission and plasticity, and affect behaviour. However, in terms of cell biology, our knowledge of the mechanisms governing the secretion of gliotransmitters is so much less detailed than our knowledge of those governing neurotransmitters that it has even been questioned whether astrocytes are capable of secreting molecules. This review critically evaluates the currently available findings concerning gliotransmitters with the aim of stimulating discussion in the field.
2016
Animals; Astrocytes; Humans; Neurotransmitter Agents
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Novel insights into gliotransmitters / Petrelli, F.; Bezzi, P.. - In: CURRENT OPINION IN PHARMACOLOGY. - ISSN 1471-4892. - 26:(2016), pp. 138-145. [10.1016/j.coph.2015.11.010]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1405264
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