A-to-I RNA editing is a post-transcriptional mechanism that converts the genomically coded Adenosine (A) into Inosine (I) at the RNA level. This type of RNA editing is the most frequent in humans and is mediated by the ADAR enzymes. RNA editing can alter the genetic code of mRNAs, but also affect the functions of noncoding RNAs such as miRNAs. Recent studies have identified thousands of microRNA editing events in different cancer types. However, the important role played by miRNA-editing in cancer has been reported for just a few microRNAs. Herein, we recapitulate the current studies on cancer-related microRNA editing and discuss their importance in tumor growth and progression.

The adaptive potential of RNA editing-mediated miRNAretargeting in cancer / Tassinari, Valentina; Cesarini, Valeriana; Alessandro Silvestris, Domenico; Gallo, Angela. - In: BIOCHIMICA ET BIOPHYSICA ACTA. GENE REGULATORY MECHANISMS. - ISSN 1874-9399. - (2019).

The adaptive potential of RNA editing-mediated miRNAretargeting in cancer

Valentina Tassinari
Primo
;
2019

Abstract

A-to-I RNA editing is a post-transcriptional mechanism that converts the genomically coded Adenosine (A) into Inosine (I) at the RNA level. This type of RNA editing is the most frequent in humans and is mediated by the ADAR enzymes. RNA editing can alter the genetic code of mRNAs, but also affect the functions of noncoding RNAs such as miRNAs. Recent studies have identified thousands of microRNA editing events in different cancer types. However, the important role played by miRNA-editing in cancer has been reported for just a few microRNAs. Herein, we recapitulate the current studies on cancer-related microRNA editing and discuss their importance in tumor growth and progression.
2019
editing, miRNA seed sequence, glioblastoma, melanoma, breast cancer
01 Pubblicazione su rivista::01a Articolo in rivista
The adaptive potential of RNA editing-mediated miRNAretargeting in cancer / Tassinari, Valentina; Cesarini, Valeriana; Alessandro Silvestris, Domenico; Gallo, Angela. - In: BIOCHIMICA ET BIOPHYSICA ACTA. GENE REGULATORY MECHANISMS. - ISSN 1874-9399. - (2019).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1403417
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