Breast surgery is classified among the procedures performed in clean surgery and is associated with a low incidence of wound infection (3-15%). The objective of this study was to evaluate the advantages antibiotic prophylaxis in patients undergoing breast surgery. A multicenter randomized controlled study was performed between January 2008 and November 2008. One thousand four hundred patients were enrolled in prospective randomized study; surgical wound infection was found in 41 patients (2.93%). In our RCT we have shown that in breast surgery antibiotic prophylaxis does not present significant advantages in patients with potential risk of infection (17 patients, 2.42%, subjected to antibiotic prophylaxis vs 24 patients, 3.43%, without antibiotic prophylaxis) (P = 0.27). In patients with drainage there is a significant minor incidence of wound infections in patients receiving antibiotic prophylaxis (5 patients, 0.92%, subjected to antibiotic prophylaxis vs 14 patients, 3.09%, without antibiotic prophylaxis) (P = 0.02). CONCLUSION: This study is only a preliminary RCT to be followed by a study which should be enrolled more patients in order to get the results as statistically significant.

Antibiotico profilassi in Chirurgia Senologica.Risultati preliminari di uno studio multicentrico randomizzato su 1400 casi trattati / Sanguinetti, A; Rosato, L; Cirocchi, R; Barberini, F; Pezzolla, A; Cavallaro, Giuseppe; Parmeggiani, D; Ruggiero, R; Docimo, G; Procaccini, E; Santoriello, A; Rulli, A; Gubitosi, A; Canonico, S; Taffurelli, M; Sciannameo, F; Barbarisi, A; Docimo, L; Agresti, M; DE TOMA, G; Noya, G; Parmeggiani, U; Avenia, N.. - In: ANNALI ITALIANI DI CHIRURGIA. - ISSN 0003-469X. - 80:(2009), pp. 275-279.

Antibiotico profilassi in Chirurgia Senologica.Risultati preliminari di uno studio multicentrico randomizzato su 1400 casi trattati

CAVALLARO, Giuseppe;DE TOMA G;
2009

Abstract

Breast surgery is classified among the procedures performed in clean surgery and is associated with a low incidence of wound infection (3-15%). The objective of this study was to evaluate the advantages antibiotic prophylaxis in patients undergoing breast surgery. A multicenter randomized controlled study was performed between January 2008 and November 2008. One thousand four hundred patients were enrolled in prospective randomized study; surgical wound infection was found in 41 patients (2.93%). In our RCT we have shown that in breast surgery antibiotic prophylaxis does not present significant advantages in patients with potential risk of infection (17 patients, 2.42%, subjected to antibiotic prophylaxis vs 24 patients, 3.43%, without antibiotic prophylaxis) (P = 0.27). In patients with drainage there is a significant minor incidence of wound infections in patients receiving antibiotic prophylaxis (5 patients, 0.92%, subjected to antibiotic prophylaxis vs 14 patients, 3.09%, without antibiotic prophylaxis) (P = 0.02). CONCLUSION: This study is only a preliminary RCT to be followed by a study which should be enrolled more patients in order to get the results as statistically significant.
2009
01 Pubblicazione su rivista::01a Articolo in rivista
Antibiotico profilassi in Chirurgia Senologica.Risultati preliminari di uno studio multicentrico randomizzato su 1400 casi trattati / Sanguinetti, A; Rosato, L; Cirocchi, R; Barberini, F; Pezzolla, A; Cavallaro, Giuseppe; Parmeggiani, D; Ruggiero, R; Docimo, G; Procaccini, E; Santoriello, A; Rulli, A; Gubitosi, A; Canonico, S; Taffurelli, M; Sciannameo, F; Barbarisi, A; Docimo, L; Agresti, M; DE TOMA, G; Noya, G; Parmeggiani, U; Avenia, N.. - In: ANNALI ITALIANI DI CHIRURGIA. - ISSN 0003-469X. - 80:(2009), pp. 275-279.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/140270
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