The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension.
Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab / Gabriel Mazia, Claudio; Wilken, Miguel; Barroso, Fabio; Saba, Juliet; Rugiero, Marcelo; Bettini, Mariela; Chaves, Marcelo; Vidal, Gonzalo; Dalila Garcia, Alejandra; De Bleecker, Jan; Van den Abeele, Guy; de Koning, Kathy; De Mey, Katrien; Mercelis, Rudy; Mahieu, Délphine; Wagemaekers, Linda; Van Damme, Philip; Depreitere, Annelies; Schotte, Caroline; Smetcoren, Charlotte; Stevens, Olivier; Van Daele, Sien; Vandenbussche, Nicolas; Vanhee, Annelies; Verjans, Sarah; Vynckier, Jan; D'Hont, Ann; Tilkin, Petra; Alves de Siqueira Carvalho, Alzira; Dias Brockhausen, Igor; Feder, David; Ambrosio, Daniel; César, Pamela; Paula Melo, Ana; Martins Ribeiro, Renata; Rocha, Rosana; Bezerra Rosa, Bruno; Veiga, Thabata; Augusto da Silva, Luiz; Santos Engel, Murilo; Gonçalves Geraldo, Jordana; da Penha Ananias Morita, Maria; Nogueira Coelho, Erica; Paiva, Gabriel; Pozo, Marina; Prando, Natalia; Dada Martineli Torres, Debora; Fernanda Butinhao, Cristiani; Duran, Gustavo; Augusto Suriane Fialho, Tomás; Cristina Gomes da Silva, Tamires; Otavio Maia Gonçalves, Luiz; Eduardo Pazetto, Lucas; Renata Cubas Volpe, Luciana; Souza Duca, Luciana; André Gheller Friedrich, Maurício; Guerreiro, Alexandre; Mohr, Henrique; Pereira Martins, Maurer; da Cruz Pacheco, Daiane; Ferreira, Luciana; Paula Macagnan, Ana; Pinto, Graziela; de Cassia Santos, Aline; Souza Bulle Oliveira, Acary; Carolina Amaral de Andrade, Ana; Annes, Marcelo; Duarte Silva, Liene; Cavalcante Lino, Valeria; Pinto, Wladimir; Assis, Natália; Carrara, Fernanda; Miranda, Carolina; Souza, Iandra; Fernandes, Patrícia; Siddiqi, Zaeem; Phan, Cecile; Narayan, Jeffrey; Blackmore, Derrick; Mallon, Ashley; Roderus, Rikki; Watt, Elizabeth; Vohanka, Stanislav; Bednarik, Josef; Chmelikova, Magda; Cierny, Marek; Toncrova, Stanislava; Junkerova Barbora Kurkova, Jana; Reguliova, Katarina; Zapletalova, Olga; Pitha, Jiri; Novakova, Iveta; Tyblova, Michaela; Jurajdova, Ivana; Wolfova, Marcela; Andersen, Henning; Harbo, Thomas; Vinge, Lotte; Krogh, Susanne; Mogensen, Anita; Vissing, John; Højgaard, Joan; Witting, Nanna; Mette Ostergaard Autzen, Anne; Pedersen, Jane; Erälinna, Juha-Pekka; Laaksonen, Mikko; Oksaranta, Olli; Harrison, Tuula; Eriksson, Jaana; Rozsa, Csilla; Horvath, Melinda; Lovas, Gabor; Matolcsi, Judit; Szabo, Gyorgyi; Jakab, Gedeonne; Szabadosne, Brigitta; Vecsei, Laszlo; Dezsi, Livia; Varga, Edina; Konyane, Monika; Antonini, Giovanni; DI PASQUALE, Antonella; Garibaldi, Matteo; Morino, Stefania; Troili, Fernanda; Fionda, Laura; Saccà, Francesco; Previous, ; Filla, Alessandro; Sub-Investigators, ; Costabile, Teresa; Marano, Enrico; Fasanaro, Angiola; Marsili, Angela; Puorro, Giorgia; Mantegazza, Renato; Antozzi, Carlo; Bonanno, Silvia; Camera, Giorgia; Locatelli, Alberta; Maggi, Lorenzo; Pasanisi, Maria; Campanella, Angela; Evoli, Amelia; Emilio Alboini, Paolo; D'Amato, Valentina; Iorio, Raffaele; Inghilleri, Maurizio; Fionda, Laura; Frasca, Vittorio; Giacomelli, Elena; Gori, MARIA CRISTINA; Lopergolo, Diego; Onesti, Emanuela; Frasca, Vittorio; Gabriele, Maria; Uzawa, Akiyuki; Kanai, Tetsuya; Kawaguchi, Naoki; Mori, Masahiro; Kaneko, Yoko; Kanzaki, Akiko; Kobayashi, Eri; Murai, Hiroyuki; Masaki, Katsuhisa; Matsuse, Dai; Matsushita, Takuya; Uehara, Taira; Shimpo, Misa; Jingu, Maki; Kikutake, Keiko; Nakamura, Yumiko; Sano, Yoshiko; Utsugisawa, Kimiaki; Nagane, Yuriko; Kamegamori, Ikuko; Tsuda, Tomoko; Fujii, Yuko; Futono, Kazumi; Ozawa, Yukiko; Mizugami, Aya; Saito, Yuka; Samukawa, Makoto; Suzuki, Hidekazu; Morikawa, Miyuki; Kamakura, Sachiko; Miyawaki, Eriko; Shiraishi, Hirokazu; Mitazaki, Teiichiro; Motomura, Masakatsu; Mukaino, Akihiro; Yoshimura, Shunsuke; Asada, Shizuka; Yoshida, Seiko; Amamoto, Shoko; Kobashikawa, Tomomi; Koga, Megumi; Maeda, Yasuko; Takada, Kazumi; Takada, Mihoko; Tsurumaru, Masako; Yamashita, Yumi; Yoshida, Seiko; Suzuki, Yasushi; Akiyama, Tetsuya; Narikawa, Koichi; Tano, Ohito; Tsukita, Kenichi; Kurihara, Rikako; Meguro, Fumie; Fukuda, Yusuke; Sato, Miwako; Okumura, Meinoshin; Funaka, Soichiro; Kawamura, Tomohiro; Makamori, Masayuki; Takahashi, Masanori; Taichi, Namie; Hasuike, Tomoya; Higuchi, Eriko; Kobayashi, Hisako; Osakada, Kaori; Imai, Tomihiro; Tsuda, Emiko; Previous, ; Shimohama, Shun; Hayashi, Takashi; Hisahara, Shin; Imai, Tomihiro; Kawamata, Jun; Murahara, Takashi; Saitoh, Masaki; Shimohama, Shun; Suzuki, Shuichiro; Yamamoto, Daisuke; Ishiyama, Yoko; Ishiyama, Naoko; Noshiro, Mayuko; Takeyama, Rumi; Uwasa, Kaori; Yasuda, Ikuko; Kim, Byung-Jo; Nyoung Lee, Chang; Seo Koo, Yong; Youl Seok, Hung; Nam Kang, Hoo; Ra, Hyejin; Joon Kim, Byoung; Bin Cho, Eun; Choi, Misong; Lee, Hyelim; Min, Ju-Hong; Seok, Jinmyoung; Lee, Jieun; Yoon Koh, Da; Kwon, Juyoung; Park, Sangae; Haw Choi, Eun; Hong, Yoon-Ho; Ahn, So-Hyun; Lim Koo, Dae; Lim, Jae-Sung; Won Shin, Chae; Ye Hwang, Ji; Kim, Miri; Min Kim, Seung; Jeong, Ha-Neul; Jung, Jinwoo; Kim, Yool-Hee; Seok Lee, Hyung; Young Shin, Ha; Bi Hwang, Eun; Shin, Miju; van der Kooi, Anneke; de Visser, Marianne; Gibson, Tamar; Casasnovas, Carlos; Antonia Alberti Aguilo, Maria; Homedes-Pedret, Christian; Julia Palacios, Natalia; Diez Porras, Laura; Velez Santamaria, Valentina; Lazaro, Ana; Diez Tejedor, Exuperio; Gomez Salcedo, Pilar; Fernandez-Fournier, Mireya; Lopez Ruiz, Pedro; Javier Rodriguez de Rivera, Francisco; Fernandez-Fournier, Mireya; Sastre, Maria; Gamez Carbonell, Josep; Sune, Pilar; Salvado Figueras, Maria; Gili, Gisela; Mazuela, Gonzalo; Illa, Isabel; Cortes Vicente, Elena; Diaz-Manera, Jordi; Antonio Querol Gutiérrez, Luis; Rojas Garcia, Ricardo; Vidal, Nuria; Arribas-Ibar, Elisabet; Piehl, Fredrik; Hietala, Albert; Bjarbo, Lena; Sengun, Ihsan; Meherremova, Arzu; Ozcelik, Pinar; Balkan, Bengu; Tuga, Celal; Ugur, Muzeyyen; Erdem-Ozdamar, Sevim; Ebru Bekircan-Kurt, Can; Pinar Acar, Nazire; Yilmaz, Ezgi; Caliskan, Yagmur; Orsel, Gulsah; Efendi, Husnu; Aydinlik, Seda; Cavus, Hakan; Kutlu, Ayse; Becerikli, Gulsah; Semiz, Cansu; Tun, Ozlem; Terzi, Murat; Dogan, Baki; Kazim Onar, Musa; Sen, Sedat; Kirbas Cavdar, Tugce; Veske, Adife; Norwood, Fiona; Dimitriou, Aikaterini; Gollogly, Jakit; Mahdi-Rogers, Mohamed; Seddigh, Arshira; Sokratous, Giannis; Maier, Gal; Sohail, Faisal; Jacob, Saiju; Sadalage, Girija; Torane, Pravin; Brown, Claire; Shah, Amna; Sathasivam, Sivakumar; Arndt, Heike; Davies, Debbie; Watling, Dave; Amato, Anthony; Cochrane, Thomas; Salajegheh, Mohammed; Roe, Kristen; Amato, Katherine; Toska, Shirli; Wolfe, Gil; Silvestri, Nicholas; Patrick, Kara; Zakalik, Karen; Katz, Jonathan; Miller, Robert; Engel, Marguerite; Forshew, Dallas; Bravver, Elena; Brooks, Benjamin; Sanjak, Mohammed; Plevka, Sarah; Burdette, Maryanne; Cunningham, Scott; Sanjak, Mohammad; Kramer, Megan; Nemeth, Joanne; Schommer, Clara; Tinerney, Scott; Juel, Vern; Guptill, Jeffrey; Hobson-Webb, Lisa; Massey, Janice; Beck, Kate; Carnes, Donna; Loor, John; Anderson, Amanda; Pascuzzi, Robert; Bodkin, Cynthia; Kincaid, John; Snook, Riley; Guinrich, Sandra; Micheels, Angela; Chaudhry, Vinay; Corse, Andrea; Mosmiller, Betsy; Kelley, Andrea; Ho, Doreen; Srinivasan, Jayashri; Vytopil, Michael; Jara, Jordan; Ventura, Nicholas; Carter, Cynthia; Donahue, Craig; Herbert, Carol; Scala, Stephanie; Weiner, Elaine; Alam, Sharmeen; Mckinnon, Jonathan; Haar, Laura; Mckinnon, Naya; Alcon, Karan; Mckenna, Kaitlyn; Sattar, Nadia; Daniels, Kevin; Jeffery, Dennis; Freimer, Miriam; Chad Hoyle, Joseph; Kissel, John; Agriesti, Julie; Chelnick, Sharon; Mezache, Louisa; Pineda, Colleen; Muharrem, Filiz; Karam, Chafic; Khoury, Julie; Previous, ; Marburger, Tessa; Kaur, Harpreet; Dimitrova, Diana; Gilchrist, James; Agrawal, Brajesh; Elsayed, Mona; Kohlrus, Stephanie; Andoin, Angela; Darnell, Taylor; Golden, Laura; Lokaitis, Barbara; Seelbach, Jenna; Muppidi, Srikanth; Goyal, Neelam; Sakamuri, Sarada; T So, Yuen; Paulose, Shirley; Pol, Sabrina; Welsh, Lesly; Bhavaraju-Sanka, Ratna; Tobon Gonzalez, Alejandro; Dishman, Lorraine; Jones, Floyd; Gonzalez, Anna; Padilla, Patricia; Saklad, Amy; Silva, Marcela; Nations, Sharon; Trivedi, Jaya; Hopkins, Steve; Kazamel, Mohamed; Alsharabati, Mohammad; Lu, Liang; Nozaki, Kenkichi; Mumfrey-Thomas, Sandi; Woodall, Amy; Mozaffar, Tahseen; Cash, Tiyonnoh; Goyal, Namita; Roy, Gulmohor; Mathew, Veena; Maqsood, Fatima; Minton, Brian; James Jones, H; Rosenfeld, Jeffrey; Garcia, Rebekah; Echevarria, Laura; Garcia, Sonia; Pulley, Michael; Aranke, Shachie; Ross Berger, Alan; Shah, Jaimin; Shabbir, Yasmeen; Smith, Lisa; Varghese, Mary; Shabbir, Yasmeen; Gutmann, Laurie; Gutmann, Ludwig; Jerath, Nivedita; Nance, Christopher; Swenson, Andrea; Olalde, Heena; Kressin, Nicole; Sieren, Jeri; Barohn, Richard; Dimachkie, Mazen; Glenn, Melanie; Mcvey, April; Pasnoor, Mamatha; Statland, Jeffery; Wang, Yunxia; Liu, Tina; Emmons, Kelley; Jenci, Nicole; Locheke, Jerry; Fondaw, Alex; Johns, Kathryn; Rico, Gabrielle; Walsh, Maureen; Herbelin, Laura; Hafer-Macko, Charlene; Kwan, Justin; Zilliox, Lindsay; Callison, Karen; Young, Valerie; Disanzo, Beth; Naunton, Kerry; Benatar, Michael; Bilsker, Martin; Sharma, Khema; Cooley, Anne; Reyes, Eliana; Michon, Sara-Claude; Sheldon, Danielle; Steele, Julie; Howard Jr, James; Karam, Chafic; Traub, Rebecca; Chopra, Manisha; Vu, Tuan; Katzin, Lara; Mcclain, Terry; Harvey, Brittany; Hart, Adam; Huynh, Kristin; Beydoun, Said; Chilingaryan, Amaiak; Doan, Victor; Droker, Brian; Gong, Hui; Karimi, Sanaz; Lin, Frank; Mcclain, Terry; Polaka, Krishna; Shah, Akshay; Tran, Anh; Akhter, Salma; Malekniazi, Ali; Tandan, Rup; Hehir, Michael; Waheed, Waqar; Lucy, Shannon; Weiss, Michael; Distad, Jane; Strom, Susan; Downing, Sharon; Kim, Bryan; Bertorini, Tulio; Arnold, Thomas; Henderson, Kendrick; Pillai, Rekha; Liu, Ye; Wheeler, Lauren; Hewlett, Jasmine; Vanderhook, Mollie; Nowak, Richard; Dicapua, Daniel; Keung, Benison; Kumar, Aditya; Patwa, Huned; Robeson, Kimberly; Yang, Irene; Nye, Joan; Vu, Hong. - In: JOURNAL OF NEUROLOGY. - ISSN 0340-5354. - (2020). [10.1007/s00415-020-09770-y]
Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab
Claudio Gabriel Mazia; Miguel Wilken; Fabio Barroso; Juliet Saba; Marcelo Rugiero; Mariela Bettini; Marcelo Chaves; Gonzalo Vidal; Alejandra Dalila Garcia; Jan De Bleecker; Guy Van den Abeele; Kathy de Koning; Katrien De Mey; Rudy Mercelis; Délphine Mahieu; Linda Wagemaekers; Philip Van Damme; Annelies Depreitere; Caroline Schotte; Charlotte Smetcoren; Olivier Stevens; Sien Van Daele; Nicolas Vandenbussche; Annelies Vanhee; Sarah Verjans; Jan Vynckier; Ann D'Hont; Petra Tilkin; Alzira Alves de Siqueira Carvalho; Igor Dias Brockhausen; David Feder; Daniel Ambrosio; Pamela César; Ana Paula Melo; Renata Martins Ribeiro; Rosana Rocha; Bruno Bezerra Rosa; Thabata Veiga; Luiz Augusto da Silva; Murilo Santos Engel; Jordana Gonçalves Geraldo; Maria da Penha Ananias Morita; Erica Nogueira Coelho; Gabriel Paiva; Marina Pozo; Natalia Prando; Debora Dada Martineli Torres; Cristiani Fernanda Butinhao; Gustavo Duran; Tomás Augusto Suriane Fialho; Tamires Cristina Gomes da Silva; Luiz Otavio Maia Gonçalves; Lucas Eduardo Pazetto; Luciana Renata Cubas Volpe; Luciana Souza Duca; Maurício André Gheller Friedrich; Alexandre Guerreiro; Henrique Mohr; Maurer Pereira Martins; Daiane da Cruz Pacheco; Luciana Ferreira; Ana Paula Macagnan; Graziela Pinto; Aline de Cassia Santos; Acary Souza Bulle Oliveira; Ana Carolina Amaral de Andrade; Marcelo Annes; Liene Duarte Silva; Valeria Cavalcante Lino; Wladimir Pinto; Natália Assis; Fernanda Carrara; Carolina Miranda; Iandra Souza; Patrícia Fernandes; Zaeem Siddiqi; Cecile Phan; Jeffrey Narayan; Derrick Blackmore; Ashley Mallon; Rikki Roderus; Elizabeth Watt; Stanislav Vohanka; Josef Bednarik; Magda Chmelikova; Marek Cierny; Stanislava Toncrova; Jana Junkerova Barbora Kurkova; Katarina Reguliova; Olga Zapletalova; Jiri Pitha; Iveta Novakova; Michaela Tyblova; Ivana Jurajdova; Marcela Wolfova; Henning Andersen; Thomas Harbo; Lotte Vinge; Susanne Krogh; Anita Mogensen; John Vissing; Joan Højgaard; Nanna Witting; Anne Mette Ostergaard Autzen; Jane Pedersen; Juha-Pekka Erälinna; Mikko Laaksonen; Olli Oksaranta; Tuula Harrison; Jaana Eriksson; Csilla Rozsa; Melinda Horvath; Gabor Lovas; Judit Matolcsi; Gyorgyi Szabo; Gedeonne Jakab; Brigitta Szabadosne; Laszlo Vecsei; Livia Dezsi; Edina Varga; Monika Konyane; Giovanni Antonini ;Antonella Di Pasquale ;Matteo Garibaldi ;Stefania Morino; Fernanda Troili ;Laura Fionda ;Francesco Saccà; Previous; Alessandro Filla; Sub-Investigators; Teresa Costabile; Enrico Marano; Angiola Fasanaro; Angela Marsili; Giorgia Puorro; Renato Mantegazza; Carlo Antozzi; Silvia Bonanno; Giorgia Camera; Alberta Locatelli; Lorenzo Maggi; Maria Pasanisi; Angela Campanella; Amelia Evoli; Paolo Emilio Alboini; Valentina D'Amato; Raffaele Iorio; Maurizio Inghilleri ;Laura Fionda; Vittorio Frasca; Elena Giacomelli; Maria Gori ;Diego Lopergolo; Emanuela Onesti ;Vittorio Frasca ;Maria Gabriele; Akiyuki Uzawa; Tetsuya Kanai; Naoki Kawaguchi; Masahiro Mori; Yoko Kaneko; Akiko Kanzaki; Eri Kobayashi; Hiroyuki Murai; Katsuhisa Masaki; Dai Matsuse; Takuya Matsushita; Taira Uehara; Misa Shimpo; Maki Jingu; Keiko Kikutake; Yumiko Nakamura; Yoshiko Sano; Kimiaki Utsugisawa; Yuriko Nagane; Ikuko Kamegamori; Tomoko Tsuda; Yuko Fujii; Kazumi Futono; Yukiko Ozawa; Aya Mizugami; Yuka Saito; Makoto Samukawa; Hidekazu Suzuki; Miyuki Morikawa; Sachiko Kamakura; Eriko Miyawaki; Hirokazu Shiraishi; Teiichiro Mitazaki; Masakatsu Motomura; Akihiro Mukaino; Shunsuke Yoshimura; Shizuka Asada; Seiko Yoshida; Shoko Amamoto; Tomomi Kobashikawa; Megumi Koga; Yasuko Maeda; Kazumi Takada; Mihoko Takada; Masako Tsurumaru; Yumi Yamashita; Seiko Yoshida; Yasushi Suzuki; Tetsuya Akiyama; Koichi Narikawa; Ohito Tano; Kenichi Tsukita; Rikako Kurihara; Fumie Meguro; Yusuke Fukuda; Miwako Sato; Meinoshin Okumura; Soichiro Funaka; Tomohiro Kawamura; Masayuki Makamori; Masanori Takahashi; Namie Taichi; Tomoya Hasuike; Eriko Higuchi; Hisako Kobayashi; Kaori Osakada; Tomihiro Imai; Emiko Tsuda; Previous; Shun Shimohama; Takashi Hayashi; Shin Hisahara; Tomihiro Imai; Jun Kawamata; Takashi Murahara; Masaki Saitoh; Shun Shimohama; Shuichiro Suzuki; Daisuke Yamamoto; Yoko Ishiyama; Naoko Ishiyama; Mayuko Noshiro; Rumi Takeyama; Kaori Uwasa; Ikuko Yasuda; Byung-Jo Kim; Chang Nyoung Lee; Yong Seo Koo; Hung Youl Seok; Hoo Nam Kang; HyeJin Ra; Byoung Joon Kim; Eun Bin Cho; MiSong Choi; HyeLim Lee; Ju-Hong Min; Jinmyoung Seok; JiEun Lee; Da Yoon Koh; JuYoung Kwon; SangAe Park; Eun Haw Choi; Yoon-Ho Hong; So-Hyun Ahn; Dae Lim Koo; Jae-Sung Lim; Chae Won Shin; Ji Ye Hwang; Miri Kim; Seung Min Kim; Ha-Neul Jeong; JinWoo Jung; Yool-Hee Kim; Hyung Seok Lee; Ha Young Shin; Eun Bi Hwang; Miju Shin; Anneke van der Kooi; Marianne de Visser; Tamar Gibson; Carlos Casasnovas; Maria Antonia Alberti Aguilo; Christian Homedes-Pedret; Natalia Julia Palacios; Laura Diez Porras; Valentina Velez Santamaria; Ana Lazaro; Exuperio Diez Tejedor; Pilar Gomez Salcedo; Mireya Fernandez-Fournier; Pedro Lopez Ruiz; Francisco Javier Rodriguez de Rivera; Mireya Fernandez-Fournier; Maria Sastre; Josep Gamez Carbonell; Pilar Sune; Maria Salvado Figueras; Gisela Gili; Gonzalo Mazuela; Isabel Illa; Elena Cortes Vicente; Jordi Diaz-Manera; Luis Antonio Querol Gutiérrez; Ricardo Rojas Garcia; Nuria Vidal; Elisabet Arribas-Ibar; Fredrik Piehl; Albert Hietala; Lena Bjarbo; Ihsan Sengun; Arzu Meherremova; Pinar Ozcelik; Bengu Balkan; Celal Tuga; Muzeyyen Ugur; Sevim Erdem-Ozdamar; Can Ebru Bekircan-Kurt; Nazire Pinar Acar; Ezgi Yilmaz; Yagmur Caliskan; Gulsah Orsel; Husnu Efendi; Seda Aydinlik; Hakan Cavus; Ayse Kutlu; Gulsah Becerikli; Cansu Semiz; Ozlem Tun; Murat Terzi; Baki Dogan; Musa Kazim Onar; Sedat Sen; Tugce Kirbas Cavdar; Adife Veske; Fiona Norwood; Aikaterini Dimitriou; Jakit Gollogly; Mohamed Mahdi-Rogers; Arshira Seddigh; Giannis Sokratous; Gal Maier; Faisal Sohail; Saiju Jacob; Girija Sadalage; Pravin Torane; Claire Brown; Amna Shah; Sivakumar Sathasivam; Heike Arndt; Debbie Davies; Dave Watling; Anthony Amato; Thomas Cochrane; Mohammed Salajegheh; Kristen Roe; Katherine Amato; Shirli Toska; Gil Wolfe; Nicholas Silvestri; Kara Patrick; Karen Zakalik; Jonathan Katz; Robert Miller; Marguerite Engel; Dallas Forshew; Elena Bravver; Benjamin Brooks; Mohammed Sanjak; Sarah Plevka; Maryanne Burdette; Scott Cunningham; Mohammad Sanjak; Megan Kramer; Joanne Nemeth; Clara Schommer; Scott Tinerney; Vern Juel; Jeffrey Guptill; Lisa Hobson-Webb; Janice Massey; Kate Beck; Donna Carnes; John Loor; Amanda Anderson; Robert Pascuzzi; Cynthia Bodkin; John Kincaid; Riley Snook; Sandra Guinrich; Angela Micheels; Vinay Chaudhry; Andrea Corse; Betsy Mosmiller; Andrea Kelley; Doreen Ho; Jayashri Srinivasan; Michael Vytopil; Jordan Jara; Nicholas Ventura; Cynthia Carter; Craig Donahue; Carol Herbert; Stephanie Scala; Elaine Weiner; Sharmeen Alam; Jonathan McKinnon; Laura Haar; Naya McKinnon; Karan Alcon; Kaitlyn McKenna; Nadia Sattar; Kevin Daniels; Dennis Jeffery; Miriam Freimer; Joseph Chad Hoyle; John Kissel; Julie Agriesti; Sharon Chelnick; Louisa Mezache; Colleen Pineda; Filiz Muharrem; Chafic Karam; Julie Khoury; Previous; Tessa Marburger; Harpreet Kaur; Diana Dimitrova; James Gilchrist; Brajesh Agrawal; Mona Elsayed; Stephanie Kohlrus; Angela Andoin; Taylor Darnell; Laura Golden; Barbara Lokaitis; Jenna Seelbach; Srikanth Muppidi; Neelam Goyal; Sarada Sakamuri; Yuen T So; Shirley Paulose; Sabrina Pol; Lesly Welsh; Ratna Bhavaraju-Sanka; Alejandro Tobon Gonzalez; Lorraine Dishman; Floyd Jones; Anna Gonzalez; Patricia Padilla; Amy Saklad; Marcela Silva; Sharon Nations; Jaya Trivedi; Steve Hopkins; Mohamed Kazamel; Mohammad Alsharabati; Liang Lu; Kenkichi Nozaki; Sandi Mumfrey-Thomas; Amy Woodall; Tahseen Mozaffar; Tiyonnoh Cash; Namita Goyal; Gulmohor Roy; Veena Mathew; Fatima Maqsood; Brian Minton; H James Jones; Jeffrey Rosenfeld; Rebekah Garcia; Laura Echevarria; Sonia Garcia; Michael Pulley; Shachie Aranke; Alan Ross Berger; Jaimin Shah; Yasmeen Shabbir; Lisa Smith; Mary Varghese; Yasmeen Shabbir; Laurie Gutmann; Ludwig Gutmann; Nivedita Jerath; Christopher Nance; Andrea Swenson; Heena Olalde; Nicole Kressin; Jeri Sieren; Richard Barohn; Mazen Dimachkie; Melanie Glenn; April McVey; Mamatha Pasnoor; Jeffery Statland; Yunxia Wang; Tina Liu; Kelley Emmons; Nicole Jenci; Jerry Locheke; Alex Fondaw; Kathryn Johns; Gabrielle Rico; Maureen Walsh; Laura Herbelin; Charlene Hafer-Macko; Justin Kwan; Lindsay Zilliox; Karen Callison; Valerie Young; Beth DiSanzo; Kerry Naunton; Michael Benatar; Martin Bilsker; Khema Sharma; Anne Cooley; Eliana Reyes; Sara-Claude Michon; Danielle Sheldon; Julie Steele; James Howard Jr; Chafic Karam; Rebecca Traub; Manisha Chopra; Tuan Vu; Lara Katzin; Terry McClain; Brittany Harvey; Adam Hart; Kristin Huynh; Said Beydoun; Amaiak Chilingaryan; Victor Doan; Brian Droker; Hui Gong; Sanaz Karimi; Frank Lin; Terry McClain; Krishna Polaka; Akshay Shah; Anh Tran; Salma Akhter; Ali Malekniazi; Rup Tandan; Michael Hehir; Waqar Waheed; Shannon Lucy; Michael Weiss; Jane Distad; Susan Strom; Sharon Downing; Bryan Kim; Tulio Bertorini; Thomas Arnold; Kendrick Henderson; Rekha Pillai; Ye Liu; Lauren Wheeler; Jasmine Hewlett; Mollie Vanderhook; Richard Nowak; Daniel Dicapua; Benison Keung; Aditya Kumar; Huned Patwa; Kimberly Robeson; Irene Yang; Joan Nye; Hong Vu
2020
Abstract
The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension.
Citazione
Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab / Gabriel Mazia, Claudio; Wilken, Miguel; Barroso, Fabio; Saba, Juliet; Rugiero, Marcelo; Bettini, Mariela; Chaves, Marcelo; Vidal, Gonzalo; Dalila Garcia, Alejandra; De Bleecker, Jan; Van den Abeele, Guy; de Koning, Kathy; De Mey, Katrien; Mercelis, Rudy; Mahieu, Délphine; Wagemaekers, Linda; Van Damme, Philip; Depreitere, Annelies; Schotte, Caroline; Smetcoren, Charlotte; Stevens, Olivier; Van Daele, Sien; Vandenbussche, Nicolas; Vanhee, Annelies; Verjans, Sarah; Vynckier, Jan; D'Hont, Ann; Tilkin, Petra; Alves de Siqueira Carvalho, Alzira; Dias Brockhausen, Igor; Feder, David; Ambrosio, Daniel; César, Pamela; Paula Melo, Ana; Martins Ribeiro, Renata; Rocha, Rosana; Bezerra Rosa, Bruno; Veiga, Thabata; Augusto da Silva, Luiz; Santos Engel, Murilo; Gonçalves Geraldo, Jordana; da Penha Ananias Morita, Maria; Nogueira Coelho, Erica; Paiva, Gabriel; Pozo, Marina; Prando, Natalia; Dada Martineli Torres, Debora; Fernanda Butinhao, Cristiani; Duran, Gustavo; Augusto Suriane Fialho, Tomás; Cristina Gomes da Silva, Tamires; Otavio Maia Gonçalves, Luiz; Eduardo Pazetto, Lucas; Renata Cubas Volpe, Luciana; Souza Duca, Luciana; André Gheller Friedrich, Maurício; Guerreiro, Alexandre; Mohr, Henrique; Pereira Martins, Maurer; da Cruz Pacheco, Daiane; Ferreira, Luciana; Paula Macagnan, Ana; Pinto, Graziela; de Cassia Santos, Aline; Souza Bulle Oliveira, Acary; Carolina Amaral de Andrade, Ana; Annes, Marcelo; Duarte Silva, Liene; Cavalcante Lino, Valeria; Pinto, Wladimir; Assis, Natália; Carrara, Fernanda; Miranda, Carolina; Souza, Iandra; Fernandes, Patrícia; Siddiqi, Zaeem; Phan, Cecile; Narayan, Jeffrey; Blackmore, Derrick; Mallon, Ashley; Roderus, Rikki; Watt, Elizabeth; Vohanka, Stanislav; Bednarik, Josef; Chmelikova, Magda; Cierny, Marek; Toncrova, Stanislava; Junkerova Barbora Kurkova, Jana; Reguliova, Katarina; Zapletalova, Olga; Pitha, Jiri; Novakova, Iveta; Tyblova, Michaela; Jurajdova, Ivana; Wolfova, Marcela; Andersen, Henning; Harbo, Thomas; Vinge, Lotte; Krogh, Susanne; Mogensen, Anita; Vissing, John; Højgaard, Joan; Witting, Nanna; Mette Ostergaard Autzen, Anne; Pedersen, Jane; Erälinna, Juha-Pekka; Laaksonen, Mikko; Oksaranta, Olli; Harrison, Tuula; Eriksson, Jaana; Rozsa, Csilla; Horvath, Melinda; Lovas, Gabor; Matolcsi, Judit; Szabo, Gyorgyi; Jakab, Gedeonne; Szabadosne, Brigitta; Vecsei, Laszlo; Dezsi, Livia; Varga, Edina; Konyane, Monika; Antonini, Giovanni; DI PASQUALE, Antonella; Garibaldi, Matteo; Morino, Stefania; Troili, Fernanda; Fionda, Laura; Saccà, Francesco; Previous, ; Filla, Alessandro; Sub-Investigators, ; Costabile, Teresa; Marano, Enrico; Fasanaro, Angiola; Marsili, Angela; Puorro, Giorgia; Mantegazza, Renato; Antozzi, Carlo; Bonanno, Silvia; Camera, Giorgia; Locatelli, Alberta; Maggi, Lorenzo; Pasanisi, Maria; Campanella, Angela; Evoli, Amelia; Emilio Alboini, Paolo; D'Amato, Valentina; Iorio, Raffaele; Inghilleri, Maurizio; Fionda, Laura; Frasca, Vittorio; Giacomelli, Elena; Gori, MARIA CRISTINA; Lopergolo, Diego; Onesti, Emanuela; Frasca, Vittorio; Gabriele, Maria; Uzawa, Akiyuki; Kanai, Tetsuya; Kawaguchi, Naoki; Mori, Masahiro; Kaneko, Yoko; Kanzaki, Akiko; Kobayashi, Eri; Murai, Hiroyuki; Masaki, Katsuhisa; Matsuse, Dai; Matsushita, Takuya; Uehara, Taira; Shimpo, Misa; Jingu, Maki; Kikutake, Keiko; Nakamura, Yumiko; Sano, Yoshiko; Utsugisawa, Kimiaki; Nagane, Yuriko; Kamegamori, Ikuko; Tsuda, Tomoko; Fujii, Yuko; Futono, Kazumi; Ozawa, Yukiko; Mizugami, Aya; Saito, Yuka; Samukawa, Makoto; Suzuki, Hidekazu; Morikawa, Miyuki; Kamakura, Sachiko; Miyawaki, Eriko; Shiraishi, Hirokazu; Mitazaki, Teiichiro; Motomura, Masakatsu; Mukaino, Akihiro; Yoshimura, Shunsuke; Asada, Shizuka; Yoshida, Seiko; Amamoto, Shoko; Kobashikawa, Tomomi; Koga, Megumi; Maeda, Yasuko; Takada, Kazumi; Takada, Mihoko; Tsurumaru, Masako; Yamashita, Yumi; Yoshida, Seiko; Suzuki, Yasushi; Akiyama, Tetsuya; Narikawa, Koichi; Tano, Ohito; Tsukita, Kenichi; Kurihara, Rikako; Meguro, Fumie; Fukuda, Yusuke; Sato, Miwako; Okumura, Meinoshin; Funaka, Soichiro; Kawamura, Tomohiro; Makamori, Masayuki; Takahashi, Masanori; Taichi, Namie; Hasuike, Tomoya; Higuchi, Eriko; Kobayashi, Hisako; Osakada, Kaori; Imai, Tomihiro; Tsuda, Emiko; Previous, ; Shimohama, Shun; Hayashi, Takashi; Hisahara, Shin; Imai, Tomihiro; Kawamata, Jun; Murahara, Takashi; Saitoh, Masaki; Shimohama, Shun; Suzuki, Shuichiro; Yamamoto, Daisuke; Ishiyama, Yoko; Ishiyama, Naoko; Noshiro, Mayuko; Takeyama, Rumi; Uwasa, Kaori; Yasuda, Ikuko; Kim, Byung-Jo; Nyoung Lee, Chang; Seo Koo, Yong; Youl Seok, Hung; Nam Kang, Hoo; Ra, Hyejin; Joon Kim, Byoung; Bin Cho, Eun; Choi, Misong; Lee, Hyelim; Min, Ju-Hong; Seok, Jinmyoung; Lee, Jieun; Yoon Koh, Da; Kwon, Juyoung; Park, Sangae; Haw Choi, Eun; Hong, Yoon-Ho; Ahn, So-Hyun; Lim Koo, Dae; Lim, Jae-Sung; Won Shin, Chae; Ye Hwang, Ji; Kim, Miri; Min Kim, Seung; Jeong, Ha-Neul; Jung, Jinwoo; Kim, Yool-Hee; Seok Lee, Hyung; Young Shin, Ha; Bi Hwang, Eun; Shin, Miju; van der Kooi, Anneke; de Visser, Marianne; Gibson, Tamar; Casasnovas, Carlos; Antonia Alberti Aguilo, Maria; Homedes-Pedret, Christian; Julia Palacios, Natalia; Diez Porras, Laura; Velez Santamaria, Valentina; Lazaro, Ana; Diez Tejedor, Exuperio; Gomez Salcedo, Pilar; Fernandez-Fournier, Mireya; Lopez Ruiz, Pedro; Javier Rodriguez de Rivera, Francisco; Fernandez-Fournier, Mireya; Sastre, Maria; Gamez Carbonell, Josep; Sune, Pilar; Salvado Figueras, Maria; Gili, Gisela; Mazuela, Gonzalo; Illa, Isabel; Cortes Vicente, Elena; Diaz-Manera, Jordi; Antonio Querol Gutiérrez, Luis; Rojas Garcia, Ricardo; Vidal, Nuria; Arribas-Ibar, Elisabet; Piehl, Fredrik; Hietala, Albert; Bjarbo, Lena; Sengun, Ihsan; Meherremova, Arzu; Ozcelik, Pinar; Balkan, Bengu; Tuga, Celal; Ugur, Muzeyyen; Erdem-Ozdamar, Sevim; Ebru Bekircan-Kurt, Can; Pinar Acar, Nazire; Yilmaz, Ezgi; Caliskan, Yagmur; Orsel, Gulsah; Efendi, Husnu; Aydinlik, Seda; Cavus, Hakan; Kutlu, Ayse; Becerikli, Gulsah; Semiz, Cansu; Tun, Ozlem; Terzi, Murat; Dogan, Baki; Kazim Onar, Musa; Sen, Sedat; Kirbas Cavdar, Tugce; Veske, Adife; Norwood, Fiona; Dimitriou, Aikaterini; Gollogly, Jakit; Mahdi-Rogers, Mohamed; Seddigh, Arshira; Sokratous, Giannis; Maier, Gal; Sohail, Faisal; Jacob, Saiju; Sadalage, Girija; Torane, Pravin; Brown, Claire; Shah, Amna; Sathasivam, Sivakumar; Arndt, Heike; Davies, Debbie; Watling, Dave; Amato, Anthony; Cochrane, Thomas; Salajegheh, Mohammed; Roe, Kristen; Amato, Katherine; Toska, Shirli; Wolfe, Gil; Silvestri, Nicholas; Patrick, Kara; Zakalik, Karen; Katz, Jonathan; Miller, Robert; Engel, Marguerite; Forshew, Dallas; Bravver, Elena; Brooks, Benjamin; Sanjak, Mohammed; Plevka, Sarah; Burdette, Maryanne; Cunningham, Scott; Sanjak, Mohammad; Kramer, Megan; Nemeth, Joanne; Schommer, Clara; Tinerney, Scott; Juel, Vern; Guptill, Jeffrey; Hobson-Webb, Lisa; Massey, Janice; Beck, Kate; Carnes, Donna; Loor, John; Anderson, Amanda; Pascuzzi, Robert; Bodkin, Cynthia; Kincaid, John; Snook, Riley; Guinrich, Sandra; Micheels, Angela; Chaudhry, Vinay; Corse, Andrea; Mosmiller, Betsy; Kelley, Andrea; Ho, Doreen; Srinivasan, Jayashri; Vytopil, Michael; Jara, Jordan; Ventura, Nicholas; Carter, Cynthia; Donahue, Craig; Herbert, Carol; Scala, Stephanie; Weiner, Elaine; Alam, Sharmeen; Mckinnon, Jonathan; Haar, Laura; Mckinnon, Naya; Alcon, Karan; Mckenna, Kaitlyn; Sattar, Nadia; Daniels, Kevin; Jeffery, Dennis; Freimer, Miriam; Chad Hoyle, Joseph; Kissel, John; Agriesti, Julie; Chelnick, Sharon; Mezache, Louisa; Pineda, Colleen; Muharrem, Filiz; Karam, Chafic; Khoury, Julie; Previous, ; Marburger, Tessa; Kaur, Harpreet; Dimitrova, Diana; Gilchrist, James; Agrawal, Brajesh; Elsayed, Mona; Kohlrus, Stephanie; Andoin, Angela; Darnell, Taylor; Golden, Laura; Lokaitis, Barbara; Seelbach, Jenna; Muppidi, Srikanth; Goyal, Neelam; Sakamuri, Sarada; T So, Yuen; Paulose, Shirley; Pol, Sabrina; Welsh, Lesly; Bhavaraju-Sanka, Ratna; Tobon Gonzalez, Alejandro; Dishman, Lorraine; Jones, Floyd; Gonzalez, Anna; Padilla, Patricia; Saklad, Amy; Silva, Marcela; Nations, Sharon; Trivedi, Jaya; Hopkins, Steve; Kazamel, Mohamed; Alsharabati, Mohammad; Lu, Liang; Nozaki, Kenkichi; Mumfrey-Thomas, Sandi; Woodall, Amy; Mozaffar, Tahseen; Cash, Tiyonnoh; Goyal, Namita; Roy, Gulmohor; Mathew, Veena; Maqsood, Fatima; Minton, Brian; James Jones, H; Rosenfeld, Jeffrey; Garcia, Rebekah; Echevarria, Laura; Garcia, Sonia; Pulley, Michael; Aranke, Shachie; Ross Berger, Alan; Shah, Jaimin; Shabbir, Yasmeen; Smith, Lisa; Varghese, Mary; Shabbir, Yasmeen; Gutmann, Laurie; Gutmann, Ludwig; Jerath, Nivedita; Nance, Christopher; Swenson, Andrea; Olalde, Heena; Kressin, Nicole; Sieren, Jeri; Barohn, Richard; Dimachkie, Mazen; Glenn, Melanie; Mcvey, April; Pasnoor, Mamatha; Statland, Jeffery; Wang, Yunxia; Liu, Tina; Emmons, Kelley; Jenci, Nicole; Locheke, Jerry; Fondaw, Alex; Johns, Kathryn; Rico, Gabrielle; Walsh, Maureen; Herbelin, Laura; Hafer-Macko, Charlene; Kwan, Justin; Zilliox, Lindsay; Callison, Karen; Young, Valerie; Disanzo, Beth; Naunton, Kerry; Benatar, Michael; Bilsker, Martin; Sharma, Khema; Cooley, Anne; Reyes, Eliana; Michon, Sara-Claude; Sheldon, Danielle; Steele, Julie; Howard Jr, James; Karam, Chafic; Traub, Rebecca; Chopra, Manisha; Vu, Tuan; Katzin, Lara; Mcclain, Terry; Harvey, Brittany; Hart, Adam; Huynh, Kristin; Beydoun, Said; Chilingaryan, Amaiak; Doan, Victor; Droker, Brian; Gong, Hui; Karimi, Sanaz; Lin, Frank; Mcclain, Terry; Polaka, Krishna; Shah, Akshay; Tran, Anh; Akhter, Salma; Malekniazi, Ali; Tandan, Rup; Hehir, Michael; Waheed, Waqar; Lucy, Shannon; Weiss, Michael; Distad, Jane; Strom, Susan; Downing, Sharon; Kim, Bryan; Bertorini, Tulio; Arnold, Thomas; Henderson, Kendrick; Pillai, Rekha; Liu, Ye; Wheeler, Lauren; Hewlett, Jasmine; Vanderhook, Mollie; Nowak, Richard; Dicapua, Daniel; Keung, Benison; Kumar, Aditya; Patwa, Huned; Robeson, Kimberly; Yang, Irene; Nye, Joan; Vu, Hong. - In: JOURNAL OF NEUROLOGY. - ISSN 0340-5354. - (2020). [10.1007/s00415-020-09770-y]
File
Dimensione
Formato
Vissing_Minimal_Symptom_Expression_2020.pdf
accesso aperto
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Creative commons
Dimensione
657.54 kB
Formato
Adobe PDF
657.54 kB
Adobe PDF
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
Sei sicuro che questo prodotto debba essere cancellato?
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande. La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.