Great concerns have been raised on SARS-CoV-2 impact on men's andrological well-being and one of the critically unanswered questions is whether it is present or not in the seminal fluid of infected subjects. The expression of ACE2 and TMPRSS2 in the testis and in the male genital tract allows speculations about a possible testicular involvement during the infection, possibly mediated by local and/or systemic inflammation that might allow a high viral load to overcome the haemato-testicular barrier. To date, few investigations have been carried out to ascertain the presence of SARS-CoV-2 in the seminal fluid with contrasting results. Furthermore, the cumulative number of subjects is far too low to answer the question unambiguously. Therefore, great caution is still needed when evaluating this data, otherwise we risk unleashing unmotivated concerns in the scientific world with troublesome consequences in reproductive medicine.

SARS-CoV-2 presence in seminal fluid: myth or reality / Paoli, Donatella; Pallotti, Francesco; Turriziani, Ombretta; Mazzuti, Laura; Antonelli, Guido; Lenzi, Andrea; Lombardo, Francesco. - In: ANDROLOGY. - ISSN 2047-2927. - (2020). [10.1111/andr.12825]

SARS-CoV-2 presence in seminal fluid: myth or reality

Paoli, Donatella
Co-primo
;
Pallotti, Francesco
Co-primo
;
Turriziani, Ombretta;Mazzuti, Laura;Antonelli, Guido;Lenzi, Andrea;Lombardo, Francesco
Ultimo
2020

Abstract

Great concerns have been raised on SARS-CoV-2 impact on men's andrological well-being and one of the critically unanswered questions is whether it is present or not in the seminal fluid of infected subjects. The expression of ACE2 and TMPRSS2 in the testis and in the male genital tract allows speculations about a possible testicular involvement during the infection, possibly mediated by local and/or systemic inflammation that might allow a high viral load to overcome the haemato-testicular barrier. To date, few investigations have been carried out to ascertain the presence of SARS-CoV-2 in the seminal fluid with contrasting results. Furthermore, the cumulative number of subjects is far too low to answer the question unambiguously. Therefore, great caution is still needed when evaluating this data, otherwise we risk unleashing unmotivated concerns in the scientific world with troublesome consequences in reproductive medicine.
2020
COVID-19; RT-PCR; SARS-CoV-2; seminal fluid; spermatozoa
01 Pubblicazione su rivista::01a Articolo in rivista
SARS-CoV-2 presence in seminal fluid: myth or reality / Paoli, Donatella; Pallotti, Francesco; Turriziani, Ombretta; Mazzuti, Laura; Antonelli, Guido; Lenzi, Andrea; Lombardo, Francesco. - In: ANDROLOGY. - ISSN 2047-2927. - (2020). [10.1111/andr.12825]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1401682
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