Objective: To report cases of use of chelation therapy during pregnancy which resulted in favorable outcomes for the babies. Materials and methods: In this retrospective cohort study, we described the evolution and outcome of 9 pregnancies in Italian thalassemic women who received deferoxamine (DFO) inadvertently during early pregnancy. Results: The use of deferoxamine during first trimester did not lead to adverse effects on the fetus or cause major complications for the gestation, although an increase in iron burden was observed after suspending chelation therapy. Conclusion: In our experience, iron-chelation therapy might be administrated in pregnancy where the benefits to the mother outweigh the potential risks to the baby.
Use of deferoxamine (DFO) in transfusion-dependent β-thalassemia during pregnancy: A retrospective study / Piccioni, M. G.; Capone, C.; Vena, F.; Del Negro, V.; Schiavi, M. C.; D'Ambrosio, V.; Giancotti, A.; Smacchia, M. P.; Brunelli, R.. - In: TAIWANESE JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 1028-4559. - 59:1(2020), pp. 120-122. [10.1016/j.tjog.2019.11.018]
Use of deferoxamine (DFO) in transfusion-dependent β-thalassemia during pregnancy: A retrospective study
Piccioni M. G.;Capone C.;Vena F.;Del Negro V.;D'Ambrosio V.;Giancotti A.;Smacchia M. P.;Brunelli R.
2020
Abstract
Objective: To report cases of use of chelation therapy during pregnancy which resulted in favorable outcomes for the babies. Materials and methods: In this retrospective cohort study, we described the evolution and outcome of 9 pregnancies in Italian thalassemic women who received deferoxamine (DFO) inadvertently during early pregnancy. Results: The use of deferoxamine during first trimester did not lead to adverse effects on the fetus or cause major complications for the gestation, although an increase in iron burden was observed after suspending chelation therapy. Conclusion: In our experience, iron-chelation therapy might be administrated in pregnancy where the benefits to the mother outweigh the potential risks to the baby.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
