Autophagy is a degradative process playing an important role in removing misfolded or aggregated proteins, clearing damaged organelles, such as mitochondria and endoplasmic reticulum, as well as eliminating intracellular pathogens. The autophagic process is important for balancing sources of energy at critical developmental stages and in response to nutrient stress. Recently, autophagy has been involved in the pathophysiology of neurodegenerative diseases although its beneficial (pro-survival) or detrimental (pro-death) role remains controversial. In the present review, we discuss the role of autophagy following intoxication with trimethyltin (TMT), an organotin compound that induces severe hippocampal neurodegeneration associated with astrocyte and microglia activation. TMT is considered a useful tool to study the molecular mechanisms occurring in human neurodegenerative diseases such as Alzheimer’s disease and temporal lobe epilepsy. This is also relevant in the field of environmental safety, since organotin compounds are used as heat stabilizers in polyvinyl chloride polymers, industrial and agricultural biocides, and as industrial chemical catalysts

Autophagy in trimethyltin-induced neurodegeneration / Pompili, Elena; Fabrizi, Cinzia; Fumagalli, Lorenzo; Fornai, Francesco. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - 127:7(2020), pp. 987-998. [10.1007/s00702-020-02210-1]

Autophagy in trimethyltin-induced neurodegeneration

Pompili, Elena
;
Fabrizi, Cinzia;Fumagalli, Lorenzo;
2020

Abstract

Autophagy is a degradative process playing an important role in removing misfolded or aggregated proteins, clearing damaged organelles, such as mitochondria and endoplasmic reticulum, as well as eliminating intracellular pathogens. The autophagic process is important for balancing sources of energy at critical developmental stages and in response to nutrient stress. Recently, autophagy has been involved in the pathophysiology of neurodegenerative diseases although its beneficial (pro-survival) or detrimental (pro-death) role remains controversial. In the present review, we discuss the role of autophagy following intoxication with trimethyltin (TMT), an organotin compound that induces severe hippocampal neurodegeneration associated with astrocyte and microglia activation. TMT is considered a useful tool to study the molecular mechanisms occurring in human neurodegenerative diseases such as Alzheimer’s disease and temporal lobe epilepsy. This is also relevant in the field of environmental safety, since organotin compounds are used as heat stabilizers in polyvinyl chloride polymers, industrial and agricultural biocides, and as industrial chemical catalysts
autophagy; trimethyltin; TMT; neurodegeneration; lithium
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Autophagy in trimethyltin-induced neurodegeneration / Pompili, Elena; Fabrizi, Cinzia; Fumagalli, Lorenzo; Fornai, Francesco. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - 127:7(2020), pp. 987-998. [10.1007/s00702-020-02210-1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1400858
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