Here, an overview of neurophysiological, pharmacological and genetic research on the role of neuropeptide tyrosine (NPY) in ethanol consumption and withdrawal is presented. NPY is abundantly expressed in the extended amygdala and is critically involved in the regulation of negative affective states in rats, also is involved 'with neurobiological responses to ethanol and other drug ofabuse. Genetic, molecular and pharmacological evidences suggest that NPY is an important neurobiological substrate for thepredisposition to alcoholism. Administration, as well as the withdrawal ofethanol, alters central NPY expression. Alcohol-preferring rats exhibit basal NPY deficits in central amygdala. In the latter, NPY may rescue dependence-induced increases in anxiety and alcohol drinking. Low NPY levels in some brain regions following ethanol withdrawal contribute to the increased sensitivity to seizure and the heightened levels of anxiety characteristic ofwithdrawal responses. Mice with deletion of NPY gene exhibit a high-anxiety, high-alcohol-drinking phenotype. Pharmacological and genetic manipulations suggest that central NPY signaling modulates ethanol consumption via Yl, Y2, and Y5 receptors. Analysis of chromosomal regions (QTLs) associated with alcohol consumption identified NPY as one of the genes that influence alcohol dependence and as a promising target for pharmacotherapeutics to combat alcohol associated disorders. Consequently, NPY is a potentially new pharmacological target for the treatment ofalcohol diseases.

Role of neuropeptide tyrosine (NPY) in ethanol addiction / Ciafrè, Stefania; Fiore, Marco; Ceccanti, Mauro; Messina, Marisa Patrizia; Tirassa, Paola; Carito, Valentina. - In: BIOMEDICAL REVIEWS. - ISSN 1314-1929. - 27:(2016), pp. 27-39.

Role of neuropeptide tyrosine (NPY) in ethanol addiction

Marco Fiore
Secondo
;
Mauro Ceccanti;Marisa Patrizia Messina;
2016

Abstract

Here, an overview of neurophysiological, pharmacological and genetic research on the role of neuropeptide tyrosine (NPY) in ethanol consumption and withdrawal is presented. NPY is abundantly expressed in the extended amygdala and is critically involved in the regulation of negative affective states in rats, also is involved 'with neurobiological responses to ethanol and other drug ofabuse. Genetic, molecular and pharmacological evidences suggest that NPY is an important neurobiological substrate for thepredisposition to alcoholism. Administration, as well as the withdrawal ofethanol, alters central NPY expression. Alcohol-preferring rats exhibit basal NPY deficits in central amygdala. In the latter, NPY may rescue dependence-induced increases in anxiety and alcohol drinking. Low NPY levels in some brain regions following ethanol withdrawal contribute to the increased sensitivity to seizure and the heightened levels of anxiety characteristic ofwithdrawal responses. Mice with deletion of NPY gene exhibit a high-anxiety, high-alcohol-drinking phenotype. Pharmacological and genetic manipulations suggest that central NPY signaling modulates ethanol consumption via Yl, Y2, and Y5 receptors. Analysis of chromosomal regions (QTLs) associated with alcohol consumption identified NPY as one of the genes that influence alcohol dependence and as a promising target for pharmacotherapeutics to combat alcohol associated disorders. Consequently, NPY is a potentially new pharmacological target for the treatment ofalcohol diseases.
2016
NPY, alcohol consumption, alcohol dependence, alcohol pharmacogenetics, alcohol neuropharmacology, amygdala
01 Pubblicazione su rivista::01a Articolo in rivista
Role of neuropeptide tyrosine (NPY) in ethanol addiction / Ciafrè, Stefania; Fiore, Marco; Ceccanti, Mauro; Messina, Marisa Patrizia; Tirassa, Paola; Carito, Valentina. - In: BIOMEDICAL REVIEWS. - ISSN 1314-1929. - 27:(2016), pp. 27-39.
File allegati a questo prodotto
File Dimensione Formato  
Ciafrè_NPY-ethanol_2016.pdf

accesso aperto

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 538.28 kB
Formato Adobe PDF
538.28 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1399380
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 21
  • ???jsp.display-item.citation.isi??? ND
social impact