Herpes simplex virus-1 (HSV-1) establishes latency preferentially in sensory neurons of peripheral ganglia. A variety of stresses can induce recurrent reactivations of the virus, which spreads and then actively replicates to the site of primary infection (usually the lips or eyes). Viral particles produced following reactivation can also reach the brain, causing a rare but severe form of diffuse acute infection, namely herpes simplex encephalitis. Most of the time, this infection is clinically asymptomatic. However, it was recently correlated with the production and accumulation of neuropathological biomarkers of Alzheimer's disease. In this review we discuss the different cellular and molecular mechanisms underlying the acute and long-term damage caused by HSV-1 infection in the brain.

Herpes simplex virus-1 in the brain. The dark side of a sneaky infection / Marcocci, Maria Elena; Napoletani, Giorgia; Protto, Virginia; Kolesova, Olga; Piacentini, Roberto; Donatella Li Puma, Domenica; Lomonte, Patrick; Grassi, Claudio; Palamara, Anna Teresa; De Chiara, Giovanna. - In: TRENDS IN MICROBIOLOGY. - ISSN 0966-842X. - (2020), pp. 1-13. [10.1016/j.tim.2020.03.003]

Herpes simplex virus-1 in the brain. The dark side of a sneaky infection

Maria Elena Marcocci
Primo
;
Giorgia Napoletani;Virginia Protto;Olga Kolesova;Anna Teresa Palamara
;
Giovanna De Chiara
2020

Abstract

Herpes simplex virus-1 (HSV-1) establishes latency preferentially in sensory neurons of peripheral ganglia. A variety of stresses can induce recurrent reactivations of the virus, which spreads and then actively replicates to the site of primary infection (usually the lips or eyes). Viral particles produced following reactivation can also reach the brain, causing a rare but severe form of diffuse acute infection, namely herpes simplex encephalitis. Most of the time, this infection is clinically asymptomatic. However, it was recently correlated with the production and accumulation of neuropathological biomarkers of Alzheimer's disease. In this review we discuss the different cellular and molecular mechanisms underlying the acute and long-term damage caused by HSV-1 infection in the brain.
File allegati a questo prodotto
File Dimensione Formato  
Marcocci_Herpes-simplex_2020.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 1.9 MB
Formato Adobe PDF
1.9 MB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1399232
Citazioni
  • ???jsp.display-item.citation.pmc??? 31
  • Scopus 55
  • ???jsp.display-item.citation.isi??? 51
social impact