Ethanol extracts of the fresh aerial parts of various Epilobium species were tested to elucidate the mechanism of their gastrointestinal activity in animals. The methods of charcoal meal, castor oil-induced diarrhoea, and enteropooling assay were used to evaluate their effect on mouse gut at various dose levels. The extracts were found to have a significant activity in all models. Moreover, the extracts resulted to possess very little toxicity. Thus, it can be concluded that Epilobium possesses anti-diarrhoeal, anti-motility, and anti-secretory activities and can prove beneficial in the treatment of gastrointestinal disorders. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Inhibition of intestinal motility and secretion by extracts of Epilobium spp. in mice / Federica, Vitali; Giuseppina, Fonte; Antonella, Saija; Tita, Beatrice. - In: JOURNAL OF ETHNOPHARMACOLOGY. - ISSN 0378-8741. - STAMPA. - 107:3(2006), pp. 342-348. [10.1016/j.jep.2006.03.025]
Inhibition of intestinal motility and secretion by extracts of Epilobium spp. in mice
TITA, Beatrice
2006
Abstract
Ethanol extracts of the fresh aerial parts of various Epilobium species were tested to elucidate the mechanism of their gastrointestinal activity in animals. The methods of charcoal meal, castor oil-induced diarrhoea, and enteropooling assay were used to evaluate their effect on mouse gut at various dose levels. The extracts were found to have a significant activity in all models. Moreover, the extracts resulted to possess very little toxicity. Thus, it can be concluded that Epilobium possesses anti-diarrhoeal, anti-motility, and anti-secretory activities and can prove beneficial in the treatment of gastrointestinal disorders. (c) 2006 Elsevier Ireland Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
