Since the new fatal pneumonia was identified in December 2019 in Wuhan, China, the WHO declared the infection a health emergency of international concern. The novel ss-RNA ß-coronavirus (SARS-CoV-2) spreads through airborne and direct contagion; virulence is high in the elderly and in patients with diabetes, chronic pulmonary, cardiovascular and neoplastic diseases. SARS-CoV-2 ssRNA is recognized by intracellular Pattern Recognition Receptors (PRRs), which trigger NF-kB - the master regulator of inflammation - and Interferon Regulatory Factors (IRFs)1 .

"Toxic erythema" and eosinophilia associated to tocilizumab therapy in a COVID-19 patient / Sernicola, Alvise; Carnicelli, Giorgia; Di Fraia, M; Chello, Camilla; Furlan, C; Muharremi, R; Paolino, Giovanni; Grieco, Teresa. - In: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. - ISSN 0926-9959. - 12:(2020), pp. 1-3. [10.1111/jdv.16620]

"Toxic erythema" and eosinophilia associated to tocilizumab therapy in a COVID-19 patient

Sernicola, Alvise
Primo
;
Carnicelli, Giorgia
Secondo
;
Chello, Camilla;Furlan, C;Muharremi, R;Paolino, Giovanni
Penultimo
;
Grieco, Teresa
Ultimo
2020

Abstract

Since the new fatal pneumonia was identified in December 2019 in Wuhan, China, the WHO declared the infection a health emergency of international concern. The novel ss-RNA ß-coronavirus (SARS-CoV-2) spreads through airborne and direct contagion; virulence is high in the elderly and in patients with diabetes, chronic pulmonary, cardiovascular and neoplastic diseases. SARS-CoV-2 ssRNA is recognized by intracellular Pattern Recognition Receptors (PRRs), which trigger NF-kB - the master regulator of inflammation - and Interferon Regulatory Factors (IRFs)1 .
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Note: https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.16620
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1392775
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