Detection of False Negative Sentinel Lymph Node in Cutaneous Oncology: A General Reappraisal

When a SLNB is expected, thewide excision of the primary cutaneous tumorshould be always combined with SLNB. The risk todetect a false negative SLN is mainly related tolymphatic mapping, radioactive labeling, surgicalmethods, pathological examination, altered lymph-atic drainage, and anatomic area where the malig-nancy is arisen. In this regard, the need for astandardization of the SLNB procedure, according toall the factors reported above, and the relative out-come measures remains a pivotal point